116557-81-4

Upstream product

• 100-44-7 benzyl chloride 
• 768-60-5 4-methoxyphenylacetylen 
• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 622-79-7 benzyl azide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 100-39-0 benzyl bromide 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 289473-23-0 diphenyl(p-methoxyphenylethynyl)stibine 
• 52999-18-5 lithium 4-methoxy-phenylacetylide 
• 556-56-9 allyl iodid 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 75-52-5 nitromethane 
• 123-11-5 4-methoxy-benzaldehyde 
• 2227-57-8 3-(4-methoxyphenyl)propynoic acid 

Downstream Products

• 874988-47-3 1-benzyl-4-(4-methoxyphenyl)-5-(p-tolyl)-1H-1,2,3-triazole 
• 1429172-06-4 1-benzyl-4-(4-methoxyphenyl)-5-phenyl-1H-1,2,3-triazole 

Relevant academic research and scientific papers

Ligand modified CuFe2O4 nanoparticles as magnetically recoverable and reusable catalyst for azide-alkyne click condensation

A ligand can make the trick: 2,2'-bipyridine was found to promote the activity of copper ferrite nanoparticles as catalysts for the azide-alkyne "click" coupling reaction. The reaction proceeded in excellent yields at room temperature, and the catalyst co

Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry

Copper nanoparticles (Cu-NPs) have a wide range of applications as heterogeneous catalysts. In this study, a novel green biosynthesis route for producing Cu-NPs using the metal-reducing bacterium, Shewanella oneidensis is demonstrated. Thin section transm

A novel route to 1,4-disubstituted-1,2,3-triazoles through metal-free decarboxylative azide-alkene cycloaddition

A collection of 1,4-disubstituted 1,2,3-triazoles was achieved by decarboxylative [3 + 2] cycloaddition of organic azides and cinnamic acids. Metal-free condition, high regioselectivity and easy accessibility of starting materials are the salient attributes of this protocol.

Homogeneous and noncovalent immobilization of NHC-Cu catalyzed azide-alkyne cycloaddition reaction

A series of new pyrene tagged nitrogen heterocyclic carbene copper (NHC-Cu) molecular complexes were synthesized and characterized by 1H- and 13C-NMR, high resolution ESI-mass spectrometry (HR-MS). The corresponding NHC-Cu complex was immobilized onto the surface of multi-walled carbon nanotubes (MWNTs) by using π-π stacking interaction, the noncovalent immobilization catalytic material MWNTs@NHC-Cu were characterized by FT-IR, XRD, XPS, thermogravimetry (TGA) and TEM. The new NHC-Cu complexes were tested both in the homogeneous phase and once immobilized onto multi-walled carbon nanotubes support for the azide-alkyne cycloaddition reaction. Both were active in the two-component click cycloaddition reaction of terminal alkynes and organic azides and three-component cycloaddition reaction that employs various terminal alkynes, NaN3 and organic halides with the advantage of excellent yields, low catalyst dosage, short reaction time. The MWNTs@NHC-Cu catalyst could be separated from the reaction system at the end of the reaction and reused in another catalytic cycle, but with loss of product yield.

vvComplexation of copper ion-containing immobilized ionic liquid in designed hierarchical-functionalized layered double hydroxide nanoreactor for azide–alkyne cycloaddition reaction

A novel nanoreactor containing Cu (II) ions which are well distributed throughout the ionic liquid-based designed layered double hydroxide is applied for azide–alkyne cycloaddition reaction. The synthesized nanocatalyst was fully characterized by thermogravimetry analysis, scanning electron microscopy, X-ray powder diffraction, Fourier transform infrared spectroscopy and Brunauer–Emmett–Teller analysis. The high surface area and the appropriate pore size of the synthesized-nanocatalyst make metal active centers accessible. On the other hand, the presence of ionic liquid in the inner layer of designed hierarchical-functionalized layered double hydroxide nanostructure creates a good environment for the leaching protection and stabilization of extremely dispersed copper ion-containing that results in good reusable features of the nanocatalyst for the synthesis of 1,4-disubstituted-1,2,3-triazole derivatives with excellent yields (75–96%) through an azide-alkyne [3 + 2] cycloaddition reaction.

A reusable efficient green catalyst of 2d cu-mof for the click and knoevenagel reaction

[Cu(CPA)(BDC)]n (CPA = 4-(Chloro-phenyl)-pyridin-4-ylmethylene-amine; BDC = 1,4-benzenedicarboxylate) has been synthesized and structurally characterized by single crystal X-Ray diffraction measurement. The structural studies establish the copper (II) containing 2D sheet with (4,4) square grid structure. The square grid lengths are 10.775 and 10.769 ?. Thermal stability is assessed by TGA, and subsequent PXRD data establish the crystallinity. The surface morphology is evaluated by FE-SEM. The N2 adsorption?desorption analysis demonstrates the mesoporous feature (～6.95 nm) of the Cu-MOF. This porous grid serves as heterogeneous green catalyst with superficial recyclability and thermal stability and facilitates organic transformations efficiently such as, Click and Knoevenagel reactions in the aqueous methanolic medium.

CuSO4 nanoparticles loaded on carboxymethylcelulose/polyaniline composites: A highly efficient catalyst with enhanced catalytic activity in the synthesis of propargylamines, benzofurans, and 1,2,3-triazoles

A novel and efficient heterogeneous CuSO4 nanoparticles (CuSO4 NPs) immobilized on carboxymethylcellulose/polyaniline (CuSO4NPs@CMC/PANI) composites were prepared via one-pot and one-step interfacial oxidative polymerizati

Magnetic Fe3O4 nanoparticles bearing CuI-NHC complexes by an “auto-click” strategy

Two copper(I)–NHC complexes bearing an azide group were reacted with alkyne-decorated magnetic Fe3O4 nanoparticles without the use of an external copper source. In the case of the least sterically congested complex, the resulting nan

Highly Efficient and Stable Atomically Dispersed Cu Catalyst for Azide-Alkyne Cycloaddition Reaction

In this study, we report a highly stable and efficient single-atom Cu dispersed on N-doped porous carbon as a superior catalyst for azide-alkyne cycloaddition reaction. A broad set of 1,4-disubstituted 1,2,3-triazoles was synthesized in high to excellent

Base-Free Copper-Catalyzed Azide-Alkyne Click Cycloadditions (CuAAc) in Natural Deep Eutectic Solvents as Green and Catalytic Reaction Media**

The click cycloaddition of azides to alkynes affording 1,2,3-triazoles is a widely used and effective chemical transformation, applied to obtain relevant products in medicine, biology, and materials science. In this work, a set of natural deep eutectic so