875-07-0Relevant academic research and scientific papers
Iterative Assembly of Macrocyclic Lactones using Successive Ring Expansion Reactions
Stephens, Thomas C.,Lawer, Aggie,French, Thomas,Unsworth, William P.
, p. 13947 - 13953 (2018/09/14)
Macrocyclic lactones can be prepared from lactams and hydroxyacid derivatives via an efficient 3- or 4-atom iterative ring expansion protocol. The products can also be expanded using amino acid-based linear fragments, meaning that macrocycles with precise
Serine protease mechanism-based mimics. Direct evidence for a transition state bridge proton in stable potentials
Bethencourt, Loengrid,Nunez, Oswaldo
, p. 2105 - 2113 (2008/09/20)
(Chemical Equation Presented) We have synthesized 1-(2-hydroxyacetyl) piperidine-2-one (2) and 1-(2-hydroxyacetyl)azepan-2-one (3). Equilibrium (Kf) between the free alcohol (open form) and the tetrahedral intermediate (cyclol) is readily estab
