875018-27-2Relevant academic research and scientific papers
Synthesis of (S)-(-)-N-acetylcolchinol using intramolecular biaryl oxidative coupling
Besong, Gilbert,Jarowicki, Krzysztof,Kocienski, Philip J.,Sliwinski, Eric,Boyle, F. Thomas
, p. 2193 - 2207 (2008/02/09)
An asymmetric synthesis of the tubulin polymerisation inhibitor (S)-(-)-N-acetylcolchinol is reported based on an intramolecular biaryl oxidative coupling of a 1,3-diarylpropyl acetamide intermediate using phenyliodonium bis(trifluoroacetate) as the final
Asymmetric synthesis of propargylamides via 3,3′-disubstituted binaphthol-modified alkynylboronates
Wu, T. Robert,Chong, J. Michael
, p. 15 - 18 (2007/10/03)
(Chemical Equation Presented) Alkynylboronates derived from 3,3′-disubstituted-2,2′-binaphthols react with various N-acylimines to give the expected chiral propargylamides with up to 99% ee. This new methodology was applied to the first enantioselective s
