63769-00-6Relevant articles and documents
Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids
Stuhr-Hansen, Nicolai,Padrah, Shahrokh,Str?mgaard, Kristian
, p. 4149 - 4151 (2014)
An effective and improved procedure is developed for the synthesis of α-hydroxy carboxylic acids by treatment of the corresponding protonated α-amino acid with tert-butyl nitrite in 1,4-dioxane-water. The amino moiety must be protonated and located α to a carboxylic acid function in order to undergo initial diazotization and successive hydroxylation, since neither β-amino acids nor acid derivatives such as esters and amides undergo hydroxylations. The method is successfully applied for the synthesis of 18 proteinogenic amino acids.
FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF
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Page/Page column 89-90, (2010/02/15)
A composition for binding FKBP proteins is disclosed, along with a method of treating conditions associated with neuronal degeneration, wherein said composition comprises a compound of Formula (I), wherein, R, R1, R2, R3 a