875153-70-1Relevant academic research and scientific papers
Image contrast agents activated by prostate specific antigen (PSA)
Jones, Graham B.,Xie, Longfei,El-Shafey, Ahmed,Crasto, Curtis F.,Bubley, Glenn J.,D'Amico, Anthony V.
, p. 3081 - 3084 (2004)
A family of image contrast agent conjugates designed to undergo enzymatic activation has been synthesized. The agents underwent activation both with enzymatically active prostate specific antigen and α-chymotrypsin, releasing free fluorophore via cleavage
An image contrast agent selectively activated by prostate specific antigen
Jones, Graham B.,Crasto, Curtis F.,Mathews, Jude E.,Xie, Longfei,Mitchell, Miguel O.,El-Shafey, Ahmed,D'Amico, Anthony V.,Bubley, Glenn J.
, p. 418 - 425 (2007/10/03)
A family of image contrast agent conjugates designed to undergo enzymatic activation has been synthesized. The agents underwent activation both with enzymatically active prostate specific antigen (PSA) and α-chymotrypsin, releasing free fluorophore via cl
Towards enzyme activated antiprostatic agents
Jones, Graham B.,Mitchell, Miguel O.,Weinberg, James S.,D'Amico, Anthony V.,Bubley, Glenn J.
, p. 1987 - 1989 (2007/10/03)
A prodrug conjugate designed to undergo activation by enzymatic prostate specific antigen has been synthesized. The prodrug system undergoes activation with PSA or α-chymotrypsin, and shows selective cytotoxicity in a PSA secreting cell line. (C) 2000 Els
