87521-75-3Relevant academic research and scientific papers
Studies in pheromone biosynthesis: Preparation of 3H labelled precursors of Drosophila pheromones
Bricard,Kunesch
, p. 2547 - 2558 (1993)
Two synthetic schemes were designed giving access to tritium labelled potential precursors of Drosophila pheromones. An intermediate in the first scheme allowed the preparation of [3H]-labelled vaccenyl acetate.
Structure-antitumor activity relationship of semi-synthetic spicamycin derivatives
Sakai,Kawai,Kamishohara,Odagawa,Suzuki,Uchida,Kawasaki,Tsuruo,Otake
, p. 1467 - 1480 (2007/10/03)
New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.
Convenient Syntheses of Bifunctional C12-Acyclic Compounds from Cyclododecanone
Bidd, Ilesh,Kelly, David J.,Ottley, Peter M.,Paynter, Oliver I.,Simmonds, Derek J.,Whiting, Mark C.
, p. 1369 - 1372 (2007/10/02)
The conversion of cyclododecanone by convenient, non-hazardous, and high-yielding reactions into a set of useful C12-bifunctional intermediates is described.Baeyer-Villiger oxidation and hydrolysis give a hydroxy acid, successively converted into the bromo acid, bromo alcohol, crude bromo aldehyde, pure bromo aldehyde ethylene acetal, and pure bromo aldehyde.Preferred reagents for the transformation CO2H -> CHO are borane-dimethyl sulphide followed by dimethyl sulphoxide-oxalyl dichloride-triethylamine.
