875210-71-2Relevant academic research and scientific papers
A new and practical boronic acid catalyzed intramolecular cyclodehydration of ureas for the synthesis of LFA-1 antagonists
Frutos, Rogelio P.,Tampone, Thomas,Mulder, Jason A.,Xu, Yibo,Reeves, Diana,Wang, Xiao-Jun,Zhang, Li,Krishnamurthy, Dhileepkumar,Senanayake, Chris H.
, p. 2465 - 2467 (2011)
A streamlined and practical approach to 1H-imidazo[1,2-α]imidazol-2- one LFA-1 antagonist (1) that features as the key step a novel intramolecular boronic acid catalyzed cyclocondensation of a urea and an amide is reported.
Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
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Page/Page column 13-14; 24, (2010/11/28)
Disclosed is an improved multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins
Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
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Page/Page column 13 - 14, (2008/06/13)
Disclosed is a multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a res
