875238-80-5Relevant academic research and scientific papers
Copper-catalyzed solvent-free redox condensation of benzothiazoles with aldehydes or benzylic alcohols
Zhang, Mingliang,Lu, Wen-Ting,Ruan, Wenqing,Zhang, Hui-Jun,Wen, Ting-Bin
, p. 1806 - 1809 (2014)
An efficient and practical method for the construction of 2-aryl-and 2-alkyl-substituted benzothiazoles via a copper-catalyzed redox condensation process between benzothiazoles and aldehydes or benzylic alcohols has been developed. The reaction proceeded under mild reaction conditions using environmentally benign tert-butyl hydroperoxide (TBHP) as the oxidant. A reaction mechanism involving the ring-opening of benzothiazoles initiated by the attack of acyl radical on the thiazole ring and intramolecular condensation is proposed based on the isolation of an anilide disulfide intermediate.
