87524-66-1

Usage

Uses

Used in Pharmaceutical Industry:
Benzeneacetic acid, 4-carboxy-, 1-Methyl ester is used as an intermediate in the synthesis of various drugs, particularly anti-inflammatory and analgesic medications. Its chemical structure allows it to be a key component in the development of these medications, contributing to their therapeutic effects.
Used in Chemical Industry:
In the chemical industry, Benzeneacetic acid, 4-carboxy-, 1-Methyl ester is utilized as a versatile intermediate for the production of other chemical compounds and materials. Its unique properties make it suitable for various chemical reactions and processes.
Used in Food Industry:
Benzeneacetic acid, 4-carboxy-, 1-Methyl ester is used as a flavoring agent in the food industry. Its ability to impart specific flavors and aromas makes it a valuable ingredient in the creation of various food products.
Safety Precautions:
It is important to handle Benzeneacetic acid, 4-carboxy-, 1-Methyl ester with caution, as it is considered hazardous and may have harmful effects if inhaled, ingested, or in contact with the skin or eyes. Proper safety measures should be taken when working with or handling this chemical to minimize potential risks and ensure the safety of those involved in its production and use.

Upstream product

• 67-56-1 methanol 
• 501-89-3 4-(carboxymethyl)benzoic acid 
• 17201-43-3 4-cyanobenzyl bromide 
• 876-31-3 4-(cyanomethyl)benzonitrile 
• 5462-71-5 4-cyanophenylacetic acid 

Downstream Products

• 1269489-12-4 2-(4-(methylcarbamoyl)phenyl)acetic acid 
• 1622242-93-6 methyl 2-(4-(methylcarbamoyl)phenyl)acetate 
• 732308-82-6 4-carboxymethyl-benzoic acid tert-butyl ester 
• 1034777-03-1 {4-[1-(5-chloro-2-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-quinolin-7-ylcarbamoyl]-phenyl}-acetic acid methyl ester 
• 1034776-09-4 {4-[1-(5-chloro-2-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-quinolin-7-ylcarbamoyl]-phenyl}-acetic acid 
• 1429653-68-8 C₂₄H₃₃NO₄Si 
• 1428731-89-8 methyl 2-(4-(benzyl(methyl)carbamoyl)phenyl)acetate 
• 1428731-73-0 N-benzyl-4-(2-(hydroxyamino)-2-oxoethyl)-N-methylbenzamide 
• 1428731-91-2 N-benzyl-N-methyl-4-(2-oxo-2-(((tetrahydro-2H-pyran-2-yl)oxy)amino)ethyl)benzamide 
• 1428731-90-1 2-(4-(benzyl(methyl)carbamoyl)phenyl)acetic acid 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR INHIBITING CYP26 ENZYMES

Compounds described herein are inhibitors of retinoic acid inducible P450 (CYP26) enzymes, and are useful for treating diseases that are responsive to retinoids. Certain compounds have retinoid activity, are resistant to CYP26-mediated catabolism, and are used for treating diseases that are responsive to retinoids.

AMIDE-LINKED EP4 AGONIST-BISPHOSPHONATE COMPOUNDS AND USES THEREOF

The present invention relates to EP4 agonist-bisphosphonate conjugates or related compounds and uses thereof. Said conjugates or related compounds may be used to provide delivery of an EP4 agonist or related compound to a desired site of action, such as a bone. Bisphosphonate moieties, linked to the EP4 agonists via amide linkers, have been implicated in the inhibition of bone resorption and bone targeting.

Metal-Free Direct Amidation of Naphthoquinones Using Hydroxamic Acids as an Amide Source: Application in the Synthesis of an HDAC6 Inhibitor

A novel synthetic approach to amidoquinones by the reaction of naphthoquinones with hydroxamic acids under basic conditions was developed. The reaction is mild and operationally simple, and it affords high yields of amidoquinones. With this new method, a novel, very strong HDAC6 inhibitor, which showed high toxicity to AML cells, was successfully synthesized.

TRISUBSTITUTED HETEROCYCLIC DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides trisubstituted heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; (I) in which R1, R2, R3, Ra, X, L, m and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the trisubstituted heterocyclic derivatives of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

HYDROXAMIC ACIDS AS HDAC6 INHIBITORS

A hydroxamic acid of formula (I) or a pharmaceutically acceptable salt thereof for use in a method for treating or preventing an immunological, inflammatory, autoimmune or allergic disorder or disease, or a transplant rejection, or a graft-versus host dis

CHEMICAL COMPOUNDS

The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.

A simple method for the preparation of monomethyl esters of dicarboxylic acids by selective esterification of the nonconjugated carboxyl group in the presence of an aromatic or conjugated carboxyl group

Various dicarboxylic acids have been converted selectively into monomethyl esters in which the nonconjugated carboxyl group is selectively esterified in the presence of an aromatic or conjugated carboxyl group at room temperature (~ 25-27°C) in methanol using a catalytic amount of thionyl chloride.

Selective esterification of nonconjugated carboxylic acids in the presence of conjugated or aromatic carboxylic acids under mild conditions

Nonconjugated carboxylic acids are selectively esterified in good yields in the presence of conjugated or aromatic carboxylic acids by stirring over Amberlyst-15 in alcohol at room temperature.

Selective esterification of aliphatic nonconjugated carboxylic acids in the presence of aromatic or conjugated carboxylic acids catalysed by NiCl2.6H2O

Unhindered aliphatic nonconjugated carboxylic acids were esterified selectively in the presence of aromatic or conjugated acids on heating in the corresponding alcoholic solutions at reflux for 3-13 hr with 10 mol% of NiCl2.6H2O catalyst.

Use of Phosphorus Pentoxide. Preparation of Half-esters through Selective Esterification

Methyl 2-,3-,4-carboxyphenylacetate and methyl 2-,3-,4-carboxyphenoxyacetate have been prepared through selective esterification of the aliphatic carboxylic acid function of the corresponding dicarboxylic acids using a mixture of phosphorus pentoxide (1 part), anhydrous copper sulphate (5 parts) and anhydrous sodium sulphate (5 parts).All the isomeric half-esters have been prepared through partial hydrolysis of the corresponding dimethylesters.