875271-90-2

Upstream product

• 875271-85-5 [2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid methyl ester 
• 164365-88-2 tert-butyl 4-bromobutylcarbamate 
• 62404-09-5 2-Phenyl-3-thienylacetic acid 
• 6270-17-3 ethyl 3-benzoylpropanoate 
• 875271-88-8 {5-[3-amino-4-(phenylethynyl)benzoyl]-2-phenylthiophene-3-yl}acetic acid methyl ester 
• 875271-84-4 [5-(3-amino-4-iodo-benzoyl)-2-phenyl-thiophen-3-yl]-acetic acid methyl ester 
• 875271-86-6 (2-phenylthiophen-3-yl)acetic acid ethyl ester 
• 875271-79-7 (2-phenylthiophen-3-yl)acetic acid methyl ester 
• 875271-83-3 [5-(4-iodo-3-nitro-benzoyl)-2-phenyl-thiophen-3-yl]-acetic acid methyl ester 
• 136343-83-4 (E)-4-Chloro-3-formyl-4-phenyl-but-3-enoic acid ethyl ester 

Downstream Products

• 875272-00-7 (4-{2-phenyl-6-[5-phenyl-4-(trityloxycarbamoyl-methyl)-thiophene-2-carbonyl]-indol-1-yl}-butyl)-carbamic acid tert-butyl ester 
• 875271-92-4 2-{5-[1-(4-N-Boc-aminobutyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}-N-hydroxyacetamide 
• 875271-91-3 [5-(1-{4-[(tert-butoxycarbonyl)amino]butyl}-2-phenyl-1H-indole-6-carbonyl)-2-phenylthiophene-3-yl]acetic acid 

Relevant academic research and scientific papers

SMALL-MOLECULE BOTULINUM TOXIN INHIBITORS

Small-molecule inhibitors of Botulinum toxin, including BoNTA, BoNTD and BoNTE are provided, as well as methods of using the inhibitors.

Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A

Botulinum neurotoxin serotype A (BoNTA) is one of the most toxic substances known. Currently, there is no antidote to BoNTA. Small molecules identified from high-throughput screening reportedly inhibit the endopeptidase-the zinc-bound, catalytic domain of