875290-69-0

Upstream product

• 853760-15-3 methyl-3-(2-hydroxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}-phenyl)propanoate 
• 75-03-6 ethyl iodide 
• 853760-12-0 7-{4-[3-Hydroxy-2-methyl-4-(3-methyl-butyryl)-phenoxy]-butoxy}-chromen-2-one 
• 664376-65-2 1-(2,4-dihydroxy-3-methylphenyl)-3-methylbutan-1-one 
• 853760-26-6 1-[4-(4-Bromo-butoxy)-2-hydroxy-3-methyl-phenyl]-3-methyl-butan-1-one 

Relevant academic research and scientific papers

3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy} phenyl)propanoic acid: A brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2)

We have identified and synthesized a brain penetrant propanoic acid as an allosteric potentiator of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward improving the potency, level of potentiation and brain penetration led to the discovery of 8 (EC 50 = 1200 nM, 77% potentiation, 119% brain/plasma in rat, 20 mpk ip, brain level of 5700 nM).