875306-64-2Relevant academic research and scientific papers
MODULATORS OF TREX1
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Paragraph 00112; 00113-00114, (2021/01/29)
Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositons thereof, which are useful for treating a variety of conditions associated with TREX1.
INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE
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Page/Page column 98; 99, (2020/11/30)
Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
NEW PESTICIDAL COMPOUNDS AND USES
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Page/Page column 130, (2015/06/11)
The invention relates to the use of known and novel phenalkyl carboxamide derivatives of the formula (I) wherein the structural elements have the meaning as indicated in the description, for the control of nematodes and/or other helminths, particularly in agriculture and in the animal health field, formulations containing such compounds, particularly agrochemical formulations, and methods for the control of nematodes and helminths. The invention further relates to novel phenalkyl carboxamide derivatives, processes for their preparation, formulations containing such compounds, methods for the control of nematodes and helminths and their use as pest controlling agents, particularly their use as nematicides and their use as anthelmintics against endoparasites in animals and humans.
2- PYRIDONE COMPOUND
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Paragraph 0353; 0354, (2016/10/08)
PROBLEM TO BE SOLVED: To provide a compound that has excellent glucokinase (GK) activating action and is useful as a pharmaceutical. SOLUTION: The present invention provides a 2-pyridone compound represented by formula [1], and a tautomer or stereoisomer of the compound, or their pharmacologically acceptable salts, or their solvates (where R1 is RA-ZA-; RA is any of a carboxy group, a sulfo group or formula [5]). COPYRIGHT: (C)2016,JPOandINPIT
SUBSTITUTED HYDANTOINS
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Page/Page column 13, (2009/07/17)
The present invention relates to compounds of the formula methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
NITROGEN-CONTAINING HETEROCYCLYL KETONES AND METHODS OF USE
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Page/Page column 190-191, (2008/12/08)
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors
Edmondson, Scott D.,Mastracchio, Anthony,He, Jiafang,Chung, Christine C.,Forrest, Michael J.,Hofsess, Scott,MacIntyre, Euan,Metzger, Joseph,O'Connor, Naphtali,Patel, Kajal,Tong, Xinchun,Tota, Michael R.,Van Der Ploeg, Lex H. T.,Varnerin, Jeff P.,Fisher, Michael H.,Wyvratt, Matthew J.,Weber, Ann E.,Parmee, Emma R.
, p. 3983 - 3987 (2007/10/03)
Aryldihydropyridazinones and aryldimethylpyrazolones with 2-benzyl vinylogous amide substituents have been identified as potent PDE3B subtype selective inhibitors. Dihydropyridazinone 8a (PDE3B IC50=0.19 nM, 3A IC50=1.3 nM) was selec
