875339-45-0Relevant articles and documents
Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy
Zhang, Zhuqing,Guo, Zuhao,Xu, Xiaowei,Cao, Danyan,Yang, Hong,Li, Yanlian,Shi, Qiongyu,Du, Zhiyan,Guo, Xiaobin,Wang, Xin,Chen, Danqi,Zhang, Ying,Chen, Lin,Zhou, Kaixin,Li, Jian,Geng, Meiyu,Huang, Xun,Xiong, Bing
, p. 16650 - 16674 (2021/12/02)
CARM1 is a protein arginine methyltransferase and acts as a transcriptional coactivator regulating multiple biological processes. Aberrant expression of CARM1 has been related to the progression of multiple types of cancers, and therefore CARM1 was consid
INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING
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Page/Page column 93-94, (2010/02/15)
The invention relates to the inhibition of vascular endothelial growth factor (VEGF) receptor signaling and hepatocyte growth factor (HGF) receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions