875433-31-1

Basic information

• Product Name: L-Alanine, N-[9-(4-bromophenyl)-9H-fluoren-9-yl]-, 1,1-dimethylethyl ester
• CAS NO: 875433-31-1
• Molecular Formula: C26H26BrNO2
• Molecular Weight: 464.402
• Mol File: 875433-31-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-[9-(4-bromophenyl)-9H-fluoren-9-yl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[9-(4-bromophenyl)-9H-fluoren-9-yl]-, 1,1-dimethylethyl ester(875433-31-1)
• EPA Substance Registry System: L-Alanine, N-[9-(4-bromophenyl)-9H-fluoren-9-yl]-, 1,1-dimethylethyl ester(875433-31-1)

Safety Data

• Hazardous Substances Data: 875433-31-1(Hazardous Substances Data)

Upstream product

• 225098-19-1 N-[9-(4-bromophenyl)-9-fluorenyl]alanine methyl ester 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 225098-20-4 (2S)-N-[9-(4-bromophenyl)-9-fluorenyl]alanine 

Downstream Products

• 58177-77-8 N-[(1,1-dimethylethoxy)carbonyl]-L-alanine 1,1-dimethylethyl ester 
• 21691-50-9 Ala-OtBu 
• 875433-34-4 N-(9-(4-morpholinophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester 
• 875433-33-3 N-(9-(4-bromophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester 
• 225098-20-4 (2S)-N-[9-(4-bromophenyl)-9-fluorenyl]alanine 
• 875433-32-2 (2S)-N-(9-(4-morpholinophenyl)-9-fluorenyl)alanine tert-butyl ester 

Relevant articles and documents

9-(4-Bromophenyl)-9-fluorenyl as a safety-catch nitro gen protecting group

The 9-(4-bromophenyl)-9-fluorenyl (BrPhF) group has been developed as a novel safety-catch amine protection. This relatively acid-stable protecting group can be successfully activated by palladium-catalyzed cross-coupling reaction of the aryl bromide with morpholine and then cleaved effectively under mild conditions using dichloroacetic acid and triethylsilane. Complementary conditions are reported for selective removal of the BrPhF group in the presence of tert-butyl esters and carbamates as well as deprotection of tert-butyl esters and carbamates in the presence of BrPhF amines.