875439-61-5

Upstream product

• 67973-80-2 3-amino-5-hydroxy-benzoic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 141311-38-8 3-tert-butoxycarbonylamino-5-hydroxy-benzoic acid methyl ester 
• 875439-69-3 3-tert-butoxycarbonylamino-5-(tert-butyl-diphenylsilanyloxy)-benzoic acid methyl ester 
• 875439-70-6 3-tert-butoxycarbonylamino-5-(tert-butyl-diphenylsilanyloxy)-benzyl alcohol 

Downstream Products

• 945859-57-4 C₃₀H₃₇NO₃Si 
• 875439-71-7 3-[3-tert-butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-1-trimethylsilyl-propyne 

Relevant academic research and scientific papers

Total syntheses of new proansamitocin derivatives by ring-closing metathesis

The enantioselective synthesis of two new proansamitocin derivatives is described. Macrocyclization is achieved by ring-closing metathesis of appropriate alkene and diene precursors. Georg Thieme Verlag Stuttgart.

Synthesis of the N-acetylcysteamine thioester of seco-proansamitocin

(Chemical Equation Presented) The enantioselective total synthesis of the N-acetylcysteamine thioester of seco-proansamitocin, a key biosynthetic intermediate of the highly potent antitumor agent ansamitocin, is described, which twice utilizes the Nagao a