67973-80-2

Usage

Synthesis Reference(s)

Tetrahedron, 39, p. 4189, 1983 DOI: 10.1016/S0040-4020(01)88639-7

InChI:InChI=1/C8H9NO3/c1-12-8(11)5-2-6(9)4-7(10)3-5/h2-4,10H,9H2,1H3

Upstream product

• 67-56-1 methanol 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 76045-71-1 3-amino-5-hydroxybenzoic acid 

Downstream Products

• 93561-92-3 methyl 5-amino-2-chloro-3-hydroxybenzoate 
• 93561-91-2 methyl 3-amino-2-chloro-5-hydroxybenzoate 
• 93561-90-1 methyl 3-amino-2,6-dichloro-5-hydroxybenzoate 
• 93561-95-6 methyl 3-amino-2,4,6-trichloro-5-hydroxybenzoate 
• 93561-96-7 methyl 3-amino-N,2,4,6-tetrachloro-5-hydroxybenzoate 
• 141311-38-8 3-tert-butoxycarbonylamino-5-hydroxy-benzoic acid methyl ester 
• 875439-70-6 3-tert-butoxycarbonylamino-5-(tert-butyl-diphenylsilanyloxy)-benzyl alcohol 
• 875439-61-5 3-tert-butoxycarbonylamino-5-(tert-butyl-diphenylsilanyloxy)-benzyl bromide 
• 875439-69-3 3-tert-butoxycarbonylamino-5-(tert-butyl-diphenylsilanyloxy)-benzoic acid methyl ester 
• 726191-28-2 methyl 3-hydroxy-5-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)benzoate 
• 1437308-51-4 methyl 6-acetylamino-8-benzyloxy-2-hydroxy-3-methylnaphthalene-1-carboxylate 
• 1437308-42-3 methyl 3-acetylamino-5-benzyloxybenzoate 
• 1437308-43-4 3-benzyloxy-5-hydroxymethylacetanilide 
• 1437308-44-5 methyl 5-(3-acetylamino-5-benzyloxy-phenyl)-4-methyl-3-oxopentanoate 

Relevant academic research and scientific papers

Two approaches to the aromatic core of the aminonaphthoquinone antibiotics

Two complementary approaches are presented for the synthesis of the quinone chromophores of the naphthoquinone ansamycins and related natural products. The first involves the use of an improved protocol for the manganese(III) acetate mediated cyclization of 5-aryl-1,3-dicarbonyl compounds to β-naphthols, leading to the simple, scalable preparation of building blocks suitable for the synthesis of naturally occurring aminonaphthoquinones. The second approach involves the Diels-Alder reaction of a series of new, ester-containing Danishefsky-type dienes with N-protected aminobenzoquinones to allow more expeditious access to similar intermediates.

THE R-ISOMER OF BETA AMINO ACID COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES

The present invention relates to a class of compounds represented by the Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the αVβ3 and/or the αV β5 integrin without significantly inhibiting the αV β6 integrin