875475-50-6Relevant academic research and scientific papers
Comparative Reactivity of 3-Methyl-5-phenylisoxazole and 3-Methyl-5-Phenylisothiazole Against Electrophilic Compounds
Alberola, Angel,Calvo, Luis,Rodriguez, M. Teresa Rodriguez,Sanudo, M. Carmen
, p. 537 - 542 (2007/10/02)
A comparative study of reactions of 3-methyl-5-phenylisoxazole and 3-methyl-5-phenylisothiazole with electrophilic compounds in the presence of n-BuLi, LICA or LICA-TMEDA is reported.By using LICA-TMEDA, regioselective reactions of heterocyclic compounds at the C-3 methyl group are obtained.With n-BuLi or LICA and the isoxazole derivative a product mixture at the C-4 position and the C-3 methyl group is found.In the case of isothiazole compound, only with methyl iodide and n-BuLi, the dialkylated product at both positions is formed.
