875587-38-5

Upstream product

• 875584-44-4 phenylmethyl 2-(tert-butyldiphenylsilyloxymethyl)-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylate 
• 501-53-1 benzyl chloroformate 
• 875584-45-5 1-phenylmethyl 2-methyl 6-(tert-butyldiphenylsilyloxymethyl)-5,6-dihydro-4H-pyridine-1,2-dicarboxylate 

Downstream Products

• 875587-40-9 phenylmethyl 6-(tert-butyldiphenylsilyloxymethyl)-2-(2-ethoxycarbonylvinyl)-3-vinylpiperidine-1-carboxylate 
• 875587-45-4 (5S,8R,8aS)-5-[(Z)-4-(tert-Butyl-diphenyl-silanyloxy)-but-1-enyl]-8-ethyl-octahydro-indolizine 
• 875587-41-0 5-(tert-butyldiphenylsilyloxymethyl)-8-ethylhexahydroindolizin-3-one 
• 875587-39-6 phenylmethyl 6-(tert-butyldiphenylsilyloxymethyl)-2-hydroxymethyl-3-vinylpiperidine-1-carboxylate 

Relevant academic research and scientific papers

Enantioselective syntheses of poison-frog alkaloids: 219F and 221I and an epimer of 193E

Enantioselective syntheses of indolizidines (-)-219F and (-)-221I have been achieved and the relative stereochemistries of natural 219F and 221I were determined by the present synthesis. A levorotatory indolizidine, corresponding to one proposed structure

Flexible syntheses of 5,8-disubstituted indolizidine poisonous-frog alkaloids via a Michael-type conjugate addition

The efficient and flexible syntheses of 5,8-disubstituted indolizidine poisonous-frog alkaloids is described using a highly stereoselective Michael-type conjugate addition reaction as the key step. In this work, syntheses of the 5,8-disubstituted indolizidine poisonous-frog alkaloids (-)-231C, (-)-221I and the proposed structure for (-)-193E are reported.