875587-41-0

Upstream product

• 875584-45-5 1-phenylmethyl 2-methyl 6-(tert-butyldiphenylsilyloxymethyl)-5,6-dihydro-4H-pyridine-1,2-dicarboxylate 
• 875587-39-6 phenylmethyl 6-(tert-butyldiphenylsilyloxymethyl)-2-hydroxymethyl-3-vinylpiperidine-1-carboxylate 
• 875587-38-5 1-phenylmethyl 2-methyl 6-(tert-butyldiphenylsilyloxymethyl)-3-vinylpiperidine-1,2-dicarboxylate 
• 875587-40-9 phenylmethyl 6-(tert-butyldiphenylsilyloxymethyl)-2-(2-ethoxycarbonylvinyl)-3-vinylpiperidine-1-carboxylate 

Downstream Products

• 875587-45-4 (5S,8R,8aS)-5-[(Z)-4-(tert-Butyl-diphenyl-silanyloxy)-but-1-enyl]-8-ethyl-octahydro-indolizine 

Relevant academic research and scientific papers

Flexible syntheses of 5,8-disubstituted indolizidine poisonous-frog alkaloids via a Michael-type conjugate addition

The efficient and flexible syntheses of 5,8-disubstituted indolizidine poisonous-frog alkaloids is described using a highly stereoselective Michael-type conjugate addition reaction as the key step. In this work, syntheses of the 5,8-disubstituted indolizidine poisonous-frog alkaloids (-)-231C, (-)-221I and the proposed structure for (-)-193E are reported.

Enantioselective syntheses of poison-frog alkaloids: 219F and 221I and an epimer of 193E

Enantioselective syntheses of indolizidines (-)-219F and (-)-221I have been achieved and the relative stereochemistries of natural 219F and 221I were determined by the present synthesis. A levorotatory indolizidine, corresponding to one proposed structure