875610-72-3

Upstream product

• 3721-37-7 cis-β-chloroacrylonitrile 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 13894-21-8 ethynyl p-tolyl sulfone 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 107-13-1 acrylonitrile 

Downstream Products

• 5697-46-1 2-Brom-3ξ--acrylonitril 
• 14028-37-6 α,β-Dibrom-β-(p-tolylsulfonyl)-propionitril 

Relevant academic research and scientific papers

Catalytic Hydrocyanation of Activated Terminal Alkynes

A universal, practical and scalable organocatalytic hydrocyanation manifold to provide β-substituted acrylonitriles bearing an electron-withdrawing functionality has been implemented. The catalytic manifold operates under the reactivity generation principle “a good nucleophile generates a strong base”, and it uses 1,4-diazabicyclo[2.2.2]octane (DABCO) as the catalyst, activated terminal alkynes as substrates and acetone cyanohydrin as the cyanide source. The acrylonitriles obtained as E,Z mixtures are straightforwardly resolved by simple flash chromatography delivering the pure isomers in preparative amounts.

PROCESS FOR THE PREPARATION OF ARYLSULFONYLPROPENENITRILES BY PHOTOCATALYTIC REACTIONS

The present invention relates to a process for the preparation of arylsulfonylpro- penenitriles. The reaction starting from arylsulfonyl iodides is catalyzed by light. The process is scalable, environmentally benign and provides the product in good yield.