87571-88-8

Basic information

• Product Name: endo-3-Aminotropane
• Synonyms: tropane-3-endo-ylamine;ENDO-3-AMINOTROPANE;endo-8-Methyl-8-azabicyclo[3.2.1]octan-3-amine;endo-3-Amino-8-methyl-8-azabicyclo[3.2.1]octane;endo-8-Methyl-3-amino-azabicyclo[3.2.1]octane;endo-8-Methyl-3-amino-aza...;(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]octan-3-amine;8-Azabicyclo[3.2.1]octan-3-amine, 8-methyl-, (3-endo)-
• CAS NO: 87571-88-8
• Molecular Formula: C₈H₁₆N₂
• Molecular Weight: 140.23
• EINECS: 1533716-785-6
• Product Categories: Heterocycle
• Mol File: 87571-88-8.mol

Chemical Properties

• Boiling Point: 91-92 °C (12 mmHg)
• Flash Point: 60.8 °C
• Appearance: /
• Density: 0.99 g/cm³
• Vapor Pressure: 0.843mmHg at 25°C
• Refractive Index: 1.507
• PKA: 11.03±0.40(Predicted)
• CAS DataBase Reference: endo-3-Aminotropane(CAS DataBase Reference)
• NIST Chemistry Reference: endo-3-Aminotropane(87571-88-8)
• EPA Substance Registry System: endo-3-Aminotropane(87571-88-8)

Safety Data

• Hazardous Substances Data: 87571-88-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Endo-3-Aminotropane is used as a stimulant for its mood-enhancing and arousal-increasing effects, making it a candidate for the treatment of certain conditions that involve low energy or mood levels.
Used in Weight-Loss Management:
Endo-3-Aminotropane is used as an anorectic agent for its appetite-suppressant effects, aiding in weight loss by reducing caloric intake.
Used in Research and Development:
Endo-3-Aminotropane serves as a subject of research for understanding the mechanisms of neurotransmitter release and reuptake inhibition, potentially leading to the development of new treatments for mood and attention disorders.

InChI:InChI=1/C8H16N2/c1-10-7-2-3-8(10)5-6(9)4-7/h6-8H,2-5,9H2,1H3/t6-,7+,8-

Upstream product

• 1515-26-0 tropinone oxime 
• 35130-97-3 (1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl-methane sulfonate 
• 532-24-1 tropinone 

Downstream Products

• 102289-05-4 diethyl-(2-chloro-benzyl)-[2-(tropane-3endo-ylaminooxalyl-amino)-ethyl]-ammonium; chloride 
• 101521-03-3 diethyl-(2-chloro-benzyl)-[3-(tropane-3endo-ylaminooxalyl-amino)-propyl]-ammonium; chloride 
• 806648-84-0 tropane-3endo-yl-carbamic acid ethyl ester 
• 114559-73-8 1-(2-Ethoxy-phenyl)-3-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-urea 
• 114559-63-6 1-(2,4-Dimethoxy-phenyl)-3-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-urea 
• 114559-87-4 2-[3-((1R,3R,5S)-8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-ureido]-benzoic acid methyl ester 
• 114559-88-5 2-[3-((1R,3R,5S)-8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-ureido]-benzoic acid ethyl ester 
• 114559-72-7 1-((1R,3R,5S)-8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(2-propoxy-phenyl)-urea 
• 114559-79-4 1-(2-Butoxy-phenyl)-3-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-urea 
• 176088-64-5 3-Methoxy-2-methyl-N-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-benzamide 
• 114559-82-9 1-((1R,3R,5S)-8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(2-phenoxy-phenyl)-urea 
• 115655-26-0 1-(2-Isopropoxy-phenyl)-3-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-urea 
• 136013-77-9 1-(2-Hydroxy-benzoyl)-3-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-urea 
• 114559-66-9 1-(2,5-Dimethoxy-phenyl)-3-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-urea 

Relevant articles and documents

A practical synthesis of 7-azaindolylcarboxy-endo-tropanamide (DF 1012)

An optimised cost-effective synthesis of the new antitussive drug, DF1012, is herewith reported. The new synthetic route to the key intermediate DF1005 is based on the unusual deprotection step of the 1-tert-butyl-3-cyano-7-azaindole intermediate, which can also be regarded as a convenient way for the industrial production of the expensive 7-azaindole 1. The second key intermediate, endo-tropanamine 6, was obtained in high yield by a novel one-pot stereoselective process using a Pd-catalysed reductive amination procedure.