endo-3-Aminotropane

Base Information

• Chemical Name: endo-3-Aminotropane
• CAS No.: 87571-88-8
• Molecular Formula: C8H16N2
• Molecular Weight: 140.228
• Hs Code.: 2933990090
• Mol file: 87571-88-8.mol

Synonyms:(3-endo)-8-Methyl-8-azabicyclo[3.2.1]octan-3-amine;

Chemical Property of endo-3-Aminotropane

Chemical Property:

• Vapor Pressure: 0.843mmHg at 25°C
• Refractive Index: 1.507
• Boiling Point: 181.6 °C at 760 mmHg
• PKA: 11.03±0.40(Predicted)
• Flash Point: 60.8 °C
• PSA: 29.26000
• Density: 0.99 g/cm³
• LogP: 1.20850

Purity/Quality:

99%, ^*data from raw suppliers

endo-8-methyl-3-amino-azabicyclo[3.2.1]octane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of endo-3-Aminotropane

There total 4 articles about endo-3-Aminotropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C15H20N2 → 3-endo-tropanamine (87571-88-8) + exo-3-amino-8-methyl-8-azabicyclo[3,2,1]octane (81487-04-9)

Guidance literature:

With platinum(IV) oxide; hydrogen; In ethanol; under 760.051 Torr; Reagent/catalyst; Pressure;

DOI:10.1021/op025570t

Reference yield:

(1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl-methane sulfonate (35130-97-3) → 3-endo-tropanamine (87571-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: palladium/charcoal; ethanolic HCl / Hydrogenation

With hydrogenchloride; palladium on activated charcoal; ethanol;

DOI:10.1021/ja01550a064

Reference yield:

tropinone (532-24-1) → 3-endo-tropanamine (87571-88-8) + exo-3-amino-8-methyl-8-azabicyclo[3,2,1]octane (81487-04-9)

Guidance literature:

Multi-step reaction with 2 steps

2: platinum(IV) oxide; hydrogen / ethanol / 760.05 Torr

With platinum(IV) oxide; hydrogen; In ethanol; 1: |Schiff Reaction;

DOI:10.1021/op025570t

upstream raw materials:

tropinone oxime

(1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl-methane sulfonate

tropinone

Downstream raw materials:

diethyl-(2-chloro-benzyl)-[2-(tropane-3endo-ylaminooxalyl-amino)-ethyl]-ammonium; chloride

diethyl-(2-chloro-benzyl)-[3-(tropane-3endo-ylaminooxalyl-amino)-propyl]-ammonium; chloride

tropane-3endo-yl-carbamic acid ethyl ester

1-(2-Ethoxy-phenyl)-3-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-urea

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