87574-15-0Relevant academic research and scientific papers
Exploration of Catalytic Activity of Quercetin Mediated Hydrothermally Synthesized NiO Nanoparticles Towards C–N Coupling of Nitrogen Heterocycles
Krishnaveni,Lakshmi,Kadirvelu,Kaveri
, p. 1628 - 1640 (2019/12/24)
Abstract: A new approach towards the preparation of phase pure NiO nanoparticles via quercetin mediated hydrothermal method is proposed in this work. The performance of quercetin as capping agent is found to be good. The XRD and SEM results confirm that the NiO nanoparticles prepared with quercetin are smaller in size and have refined morphology than that prepared without quercetin. Thermal stability, elemental composition and particle size of prepared nanoparticles have been revealed by TG-DSC, EDAX and HR-TEM analysis respectively. N2 adsorption–desorption isotherm (BET) analysis was done to reveal specific surface area. The prepared NiO nanoparticles act as cost effective, environmental friendly and efficient catalyst for the C–N cross coupling of indole and electron deficient pyrrole, under very mild reaction conditions. The catalytic system is able to tolerate many functional groups with different electronic and structural properties. Hence the present catalytic system may be possibly applied in large scale synthesis. Graphic Abstract: [Figure not available: see fulltext.].
N-Bromosuccinimide-Induced C-H Bond Functionalization: An Intramolecular Cycloaromatization of Electron Withdrawing Group Substituted 1-Biphenyl-2-ylethanone for the Synthesis of 10-Phenanthrenol
Jiang, Ya-Ting,Yu, Zhen-Zhen,Zhang, Ya-Kai,Wang, Bin
supporting information, p. 3728 - 3731 (2018/07/25)
An NBS-induced intramolecular cycloaromatization for the synthesis of 10-phenanthrenols from electron-withdrawing group substituted 1-biphenyl-2-ylethanones is described. The in situ generated bromide was designed to act as an initiator for the radical C-H bond activation. An oxidative cross-dehydrogenative coupling reaction of a highly active C-H bond with an inert C-H bond readily occurs under mild conditions without the need for transition metals or strong oxidants.
A multi-substituted 10 - hydroxyl philippines and its derivative and its synthesis method
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Paragraph 0153; 0156, (2019/01/08)
The invention provides a multi-substituted 10 - hydroxyl philippines and its derivative and its synthesis method, the method comprises: formula (1) compounds in the [...], additive, peroxide and organic solvent under the action of the [...] (2) compound,
Iron-Catalyzed Intramolecular C(sp2)-N Cyclization of 1-(N-Arylpyrrol-2-yl)ethanone O-Acetyl Oximes toward Pyrrolo[1,2-a]quinoxaline Derivatives
Zhang, Zhiguo,Li, Junlong,Zhang, Guisheng,Ma, Nana,Liu, Qingfeng,Liu, Tongxin
supporting information, p. 6875 - 6884 (2015/10/06)
An efficient and convenient iron-catalyzed protocol has been developed for the synthesis of substituted pyrrolo[1,2-a]quinoxalines from 1-(N-arylpyrrol-2-yl)ethanone O-acetyl oximes through N-O bond cleavage and intramolecular directed C-H arylation reactions in acetic acid.
Practical copper-catalyzed N-arylation of nitrogen heterocycles with aryl halides under ligand and additive free conditions
Chang, Joyce Wei Wei,Xu, Xiuhui,Chan, Philip Wai Hong
, p. 245 - 248 (2007/10/03)
N-arylation of a wide variety of nitrogen heterocycles with aryl iodides catalyzed by copper iodide under mild ligand and additive free conditions (nBu4NBr, PhMe, NaOH, reflux, 22 h) was accomplished in good to excellent yields (up to 95%) and substrate conversions (up to 99%).
Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles
Antilla, Jon C.,Baskin, Jeremy M.,Barder, Timothy E.,Buchwald, Stephen L.
, p. 5578 - 5587 (2007/10/03)
This paper details the copper-catalyzed N-arylation of π-excessive nitrogen heterocycles. The coupling of either aryl iodides or aryl bromides with common nitrogen heterocycles (pyrroles, pyrazoles, indazoles, imidazoles, and triazoles) was successfully performed in good yield with catalysts derived from diamine ligands and CuI. General conditions were found that tolerate functional groups such as aldehydes, ketones, alcohols, primary amines, and nitriles on the aryl halide or heterocycle. Hindered aryl halides or heterocycles were also found to be suitable substrates using the conditions reported herein.
Pyrrole Studies. Part 28. The Effect of Steric Hindrance upon the Reaction of 2-Vinylpyrroles with Dimethyl Acetylenedicarboxylate
Jones, R. Alan,Saliente, Teresa Aznar,Arques, Jose Sepulveda
, p. 2541 - 2543 (2007/10/02)
Steric interaction between the N-substituent and the vinyl substituent of 1-substituted 1-(1-substituted pyrrol-2-yl)ethenes destabilises the cisoid conformation (1b), thereby inhibiting (?4+?2) cycloaddition reactions leading to dihydroindoles.Bulky N-substituents also sterically inhibit the Michael addition of dimethyl acetylenedicarboxylate at the 5-position of the pyrrole ring.
Synthesis of Some Pyrrolobenzothiazepines via N-Aryl-2-thiocyanatopyrroles
Cheeseman, G. W. H.,Hawi, A. A.
, p. 585 - 590 (2007/10/02)
Pyrrolobenzothiazepines were successfully synthesised from alkylthiopyrroles.The latter compounds were prepared from the appropriate N-aryl-2-thiocyanatopyrroles. 2,3-Dihydro-3-oxo-4-phenylthienopyrrole (29) was obtained from acid treatment of the 2-pyrrolylthioacetic acid 28.
