875768-23-3Relevant academic research and scientific papers
A novel chiral ferrocene-based amidine/amidinato ligand and its rhodium complexes
Bertogg, Andreas,Togni, Antonio
, p. 622 - 630 (2006)
The N,N′-bisferrocenyl-substituted chiral formamidine 1 (N,N′-bis[(S)-2-{(1R)-1-(diphenylphosphino)-ethyl}ferrocen-1-yl] formamidine) was prepared from commercially available {(1R)-1-(dimethylamino)- ethyl}ferrocene by a multistep procedure in an overall yield of 29%. Deprotonation of 1 followed by addition of [Rh2Cl2(COD) 2] yielded the (formamidinato)rhodium(I) complex 2 [(N,N′-bis[(S)-2-{(1R)-1-(diphenylphosphino)ethyl}ferrocen-1-yl] formamidinato)rhodium(I)]. Direct reaction of formamidine 1 with [Rh 2Cl2(COD)2] led to complex 10 [(κ-N,P-bis[(S)-2-{(1R)-1-(diphenylphosphino)ethyl}ferrocen-1-yl] formamidine)(chloro)(η4-1,5-cyclooctadiene)rhodium(I)], which was converted to 2 upon addition of base. Oxidative addition of methyl chloride or methyl iodide to 2 yielded the trans adducts 11 [(N,N′-bis[(S)-2-{(1R)-1- (diphenylphosphino)ethyl}ferrocen-1-yl]formamidinato)(chloro)(methyl) rhodium(III)] and 12 [(N,N′-bis[(S)-2-{(1R)-1-(diphenylphosphino)ethyl} ferrocen-1-yl]formamidinato)(iodo)(methyl)-rhodium(III)], the configurations of which were determined by means of NMR and, in the case of the Rh(III) methyl chloride adduct 11, by X-ray analysis.
AMINO-PHOSPHINOALKYL-FERROCENES AND THEIR USE AS LIGANDS IN CATALYSTS FOR ASYMMETRIC REACTIONS
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Page/Page column 19, (2010/11/26)
Compounds of the formulae (I) and (V) in the form of racemates, mixtures of stereoisomers or optically pure stereoisomers, where R is unsubstituted or F-, Cl-, OH-, C1-C4-alkyl- or C1-C4-alkoxy-subsituted C1-C8-alkyl, C3-C8-cycloalkyl-C1-C4-alkyl or C7-C11 i-aralkyl; X1 is a secondary phosphino group; Ri is C1-C4-alkyl or phenyl; and n is 0 or from 1 to 5. The compounds are ligands for the formation of catalytically active metal complexes as asymmetric, homogeneous catalysts.
