87581-75-7Relevant academic research and scientific papers
ALPHA-LITHIATION OF N-ALKYL GROUPS IN PYRAZOLES
Katritzky, Alan R.,Jayaram, Chandra,Vassilatos, Socrates N.
, p. 2023 - 2029 (1983)
1,3,5-Trimethylpyrazole and 1-ethyl-3,5-dimethylpyrazole undergo lithiation exclusively at the α-position of the N-alkyl group. 1-Benzylpyrazole is metallated under kinetic control at -78 deg C at the CH2 group, but the metallorganic intermediate rearrang
