ALPHA-LITHIATION OF N-ALKYL GROUPS IN PYRAZOLES

DOI: 10.1016/S0040-4020(01)91920-9

Source and publish data:

Tetrahedron p. 2023 - 2029 (1983)

Update date:2022-08-05

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Authors:

Katritzky, Alan R.

Jayaram, Chandra

Vassilatos, Socrates N.

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Article abstract of DOI:10.1016/S0040-4020(01)91920-9

1,3,5-Trimethylpyrazole and 1-ethyl-3,5-dimethylpyrazole undergo lithiation exclusively at the α-position of the N-alkyl group. 1-Benzylpyrazole is metallated under kinetic control at -78 deg C at the CH2 group, but the metallorganic intermediate rearrang

Full text of DOI:10.1016/S0040-4020(01)91920-9

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