875858-80-3

Basic information

• Product Name: 2-(4-FLUORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE
• Synonyms: 2-(4-FLUOROPHENYL)-1,3-THIAZOLE-4-CARBALDEHYDE;2-(4-FLUORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE;4-Thiazolecarboxaldehyde, 2-(4-fluorophenyl)-;2-(4-fluorophenyl)-4-Thiazolecarboxaldehyde
• CAS NO: 875858-80-3
• Molecular Formula: C10H6FNOS
• Molecular Weight: 207.22
• Mol File: 875858-80-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 346.145 °C at 760 mmHg
• Flash Point: 163.143 °C
• Appearance: /
• Density: 1.352g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-FLUORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE(875858-80-3)
• EPA Substance Registry System: 2-(4-FLUORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE(875858-80-3)

Safety Data

• Hazardous Substances Data: 875858-80-3(Hazardous Substances Data)

Usage

General Description

2-(4-Fluoro-Phenyl)-Thiazole-4-Carbaldehyde is a specific compound that falls under the category of organofluorine compounds. It's characterized by a fluorine atom attached to a phenyl group, combined with a thiazole ring, and a carbaldehyde group. The chemical structure ensures its importance and possible use in several research areas, particularly in medicinal chemistry and drug design, due to its potential pharmacological properties. While there is limited information regarding its toxicity, a comprehensive understanding of its properties needs further study.

InChI:InChI=1/C10H6FNOS/c11-8-3-1-7(2-4-8)10-12-9(5-13)6-14-10/h1-6H

Upstream product

• 132089-35-1 ethyl 2-(4-fluorophenyl)thiazole-4-carboxylate 
• 22179-72-2 4-fluorothiobenzamide 
• 863668-07-9 2-(4-fluorophenyl)-1,3-thiazole-4-carboxylic acid 
• 1765-93-1 4-fluoroboronic acid 

Relevant articles and documents

Synthesis of new 2-(thiazol-4-yl)thiazolidin-4-one derivatives as potential anti-mycobacterial agents

To search for potent antimycobacterial lead compounds, a new series of 3-substituted phenyl-2-(2-(substituted phenyl)thiazol-4-yl) thiazolidin-4-one (5a-t) derivatives have been synthesized by the condensation of 2-substituted phenyl thiazole-4-carbaldehy

Synthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives

The increase in antibiotic resistance due to multiple factors has warranted the need for search of new compounds which are active against multidrug resistant pathogens. In this context a small focused library of thiosemicarbazide derivatives of 2-arylthiazole-4-carbaldehyde, 4-methyl-2-arylthiazole-5-carbaldehyde and 1-(4-methyl-2-arylthiazol-5-yl) ethanone, (5a–l) has been synthesized. The title compounds were screened for inhibitory activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and Mycobacterium bovis Bacille Calmette Guerin (ATCC 35743) strains. The synthesized compounds, 5a–l were further assayed for their cytotoxic activity against the two human cancer cell lines, HeLa and human colon carcinoma 116 cell lines and showed no significant cytotoxic activity against these two cell lines at the maximum concentration evaluated. Further, the synthesized compounds were found to have potential antibacterial activity against Gram-negative bacteria, Escherichia coli, Pseudomonas flurescence and Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis. Most of the synthesized compounds showed moderate activity against fungal strain Candida albicans. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimycobacterial agent.