875917-30-9Relevant academic research and scientific papers
Discovery of N -[(2 s)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1 H -inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator
Ward, Simon E.,Harries, Mark,Aldegheri, Laura,Andreotti, Daniele,Ballantine, Stuart,Bax, Benjamin D.,Harris, Andrew J.,Harker, Andy J.,Lund, Jesper,Melarange, Rosemary,Mingardi, Anna,Mookherjee, Claudette,Mosley, Julie,Neve, Marta,Oliosi, Beatrice,Profeta, Roberto,Smith, Kathrine J.,Smith, Paul W.,Spada, Simone,Thewlis, Kevin M.,Yusaf, Shahnaz P.
experimental part, p. 5801 - 5812 (2010/11/05)
A series of AMPA receptor positive allosteric modulators has been optimized from poorly penetrant leads to identify molecules with excellent preclinical pharmacokinetics and CNS penetration. These discoveries led to 17i, a potent, efficacious CNS penetrant molecule with an excellent pharmacokinetic profile across preclinical species, which is well tolerated and is also orally bioavailable in humans.
COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE
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Page/Page column 31-32, (2010/10/19)
Compounds of formula (I), a pharmaceutically acceptable salt, solvate or prodrug thereof are disclosed: wherein R1 is C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, amino, monoC1-4alkylamino or diC1 4alkylamino; R2 and R3, which may be the same or different, are
