875929-96-7Relevant academic research and scientific papers
Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model
Depauw, Sabine,Lambert, Mélanie,Jambon, Samy,Paul, Ananya,Peixoto, Paul,Nhili, Raja,Marongiu, Laura,Figeac, Martin,Dassi, Christelle,Paul-Constant, Charles,Billoré, Benjamin,Kumar, Arvind,Farahat, Abdelbasset A.,Ismail, Mohamed A.,Mineva, Ekaterina,Sweat, Daniel P.,Stephens, Chad E.,Boykin, David W.,Wilson, W. David,David-Cordonnier, Marie-Hélène
, p. 1306 - 1329 (2019)
Most transcription factors were for a long time considered as undruggable targets because of the absence of binding pockets for direct targeting. HOXA9, implicated in acute myeloid leukemia, is one of them. To date, only indirect targeting of HOXA9 expres
Dicationic compounds which selectively recognize G-quadruplex DNA
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Page/Page column 35; 39-40, (2008/06/13)
Dicationic compounds that are highly selective for binding G-quadruplex DNA are described. Several compounds exhibit groove binding toward G-quadruplex DNA and in vitro and in vivo activity versus Trypanosoma brucei rhodesiense. The compounds represent no
