87596-30-3Relevant academic research and scientific papers
1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies
La Regina, Giuseppe,D'Auria, Felicia Diodata,Tafi, Andrea,Piscitelli, Francesco,Olla, Stefania,Caporuscio, Fabiana,Nencioni, Lucia,Cirilli, Roberto,La Torre, Francesco,De Melo, Nadja Rodrigues,Kelly, Steven L.,Lamb, David C.,Artico, Marino,Botta, Maurizio,Palamara, Anna Teresa,Silvestri, Romano
experimental part, p. 3841 - 3855 (2009/04/11)
New 1-[(3-aryloxy-3-aryl)propyl]-1H-imidazoles were synthesized and evaluated against Candida albicans and dermatophytes in order to develop structure-activity relationships (SARs). Against C. albicans the new imidazoles showed minimal inhibitory concentrations (MICs) comparable to those of ketoconazole, miconazole, and econazole, and were more potent than fluconazole. Several derivatives (10, 12, 14, 18-20, 24, 28, 29, 30, and 34) turned out to be potent inhibitors of C. albicans strains resistant to fluconazole, with MIC values less than 10 μg/mL. Against dermatophytes strains, compounds 20, 25, and 33 (MIC ≤ 5 μg/mL) were equipotent to ketoconazole, econazole, and miconazole. SARs of imidazoles 10-44 were rationalized with reasonable accuracy by a previously developed quantitative pharmacophore for antifungal agents.
NOVEL BENZODIOXOLES
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Page 150, (2008/06/13)
The present invention relates to compound of formula (I) Wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases, which are associated with the modulation of CB1 receptors.
