87597-22-6

Usage

Uses

Used in Pharmaceutical Industry:
IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER is used as a chemical intermediate for the synthesis of pharmaceutical drugs. Its unique structure and potential biological activities make it a promising candidate for the development of new drugs with therapeutic benefits.
Used in Medicinal Chemistry:
IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER is used as a research compound in medicinal chemistry. Its unique structure allows scientists to study its interactions with biological targets and evaluate its potential as a lead compound for drug discovery.
Used in Drug Discovery:
IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER is used as a starting point for drug discovery. Its potential biological activities and unique structure make it an interesting candidate for further research and development into new therapeutic agents.

Upstream product

• 5049-61-6 2-Aminopyrazine 
• 922-19-0 methyl 3-chloro-2-oxo-propanoate 
• 7425-63-0 methyl 3-bromo-2-oxopropanoate 

Downstream Products

• 91476-81-2 tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazinecarboxylate-2 de methyle 

Relevant academic research and scientific papers

Derives N-nitres et N-nitroses en serie tetrahydro-5,6,7,8 imidazopyrazinique : obtention et determination par RMN 1H des configurations Z et E.

Les derives N-nitres et N-nitroses en serie tetrahydro-5,6,7,8 imidazopyrazinique sont obtenus simultanement lors de la nitration par HNO3 (d = 1.51) en milieu sulfurique.L'analyse des isomeres N-nitroses Z et E met en evidence l'apparition preponderante de la forme Z ainsi qu'une restriction importante a son equilibration.La stabilite particuliere de l'isomere Z est attribuee a l'existence d'une assistance electronique preferentielle entre groupement nitroso et protons en position 8.

Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties

A series of imidazo[1,2-a]pyrazine derivatives was synthesized by condensation of α-halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo[1,2-a]pyrazine showed positive chronotropic and inotropic properties; the latter was associated with an increase in the cyclic AMP tissue concentration. Potentiation of the isoproterenol positive inotropic effect of 5-bromoimidazo[1,2-a]pyrazine and the lack of blockade of the 5-bromoimidazo[1,2-a]pyrazine positive inotropic effect by propranolol suggested phosphodiesterase-inhibiting properties.