876065-74-6

Upstream product

• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 13005-36-2 potassium phenylacetate 
• 103-82-2 phenylacetic acid 
• 574-98-1 2-(2-bromoethyl)isoindoline-1,3-dione 
• 6921-34-2 benzylmagnesium chloride 

Downstream Products

• 876065-77-9 3-benzyl-2-(2-phenylsulfanylethyl)-2,3-dihydroisoindol-1-one 
• 876065-73-5 3-benzyl-2,3-dihydro-2-(2-phenylthioethyl)-isoindol-1-one 
• 876065-76-8 3-benzyl-2-(2-chloroethyl)-2,3-dihydroisoindol-1-one 
• 876065-78-0 (3-benzyl-1,3-dihydro-1-oxoisoindol-2-yl)acetaldehyde 
• 876065-75-7 3-benzyl-2-(2-hydroxyethyl)-2,3-dihydroisoindol-1-one 

Relevant academic research and scientific papers

Oxidized isoquinolinoisoindolinone and benzazepinoisoindolinone alkaloids cores by convergent cyclisation processes: π-aromatic attack of thionium and oxonium species

An efficient methodology for synthesis of isoindoloisoquinoline 5a and isoindolobenzazepine 5b in oxidized forms as tetracyclic alkaloids cores are reported from N-bromoethylphthalimide (6) or phthalic anhydride and 2-phenylthioethylamine (8) in a five- o

Erratum: Continuous-Flow Photochemical Transformations of 1,4-Naphthoquinones and Phthalimides in a Concentrating Solar Trough Reactor (Aust. J. Chem. (2020) 73(12):1149-1157)

The authors wish to advise of errors in the above paper. In Table 3, footnote C should read 'Crude product contains 4-methylanisole or p-tolyl acetate.' In the left column of text on the same page as Table 3, the second last sentence should read 'When the para-substituted arylacetates 9b and 9c were employed, 4-methylanisole and p-tolyl acetate were detected by 1H NMR analysis of the crude reaction mixtures but no attempts were made to isolate these simple decarboxylation products.'

The photodecarboxylative addition of carboxylates to phthalimides as a key-step in the synthesis of biologically active 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones

The synthesis of various 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones was realized following a simple three-step process. The protocol utilized the photodecarboxylative addition of readily available carboxylates to N-(bromoalkyl)phthalimides as a versatile and efficient key step. The initially obtained hydroxyphthalimidines were readily converted to the desired N-diaminoalkylated 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones via acid-catalyzed dehydration and subsequent nucleophilic substitution with the corresponding secondary amines. The procedure was successfully applied to the synthesis of known local anesthetics (AL-12, AL-12B and AL-5) in their neutral forms.