876159-76-1 Usage
Uses
Used in Chemical Research:
(3R)-1-(4-chlorobenzoyl)-3-pyrrolidinamine is used as a research compound for studying its chemical properties and potential interactions with other molecules. Its unique structure and chirality make it an interesting subject for understanding various chemical reactions and mechanisms.
Used in Pharmaceutical Development:
In the pharmaceutical industry, (3R)-1-(4-chlorobenzoyl)-3-pyrrolidinamine is used as a starting material or intermediate in the synthesis of various drugs. Its specific functional groups and chirality can be exploited to design and develop new pharmaceuticals with desired biological activities.
Used in Drug Synthesis:
(3R)-1-(4-chlorobenzoyl)-3-pyrrolidinamine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for further functionalization and modification to create new drug candidates with potential therapeutic applications.
Used in Chiral Chemistry:
Due to its chiral nature, (3R)-1-(4-chlorobenzoyl)-3-pyrrolidinamine is used in chiral chemistry to study the effects of stereochemistry on the properties and reactivity of molecules. This can lead to a better understanding of the role of chirality in biological systems and the development of enantiomerically pure drugs.
Used in Analytical Chemistry:
(3R)-1-(4-chlorobenzoyl)-3-pyrrolidinamine can be used as a chiral reference standard in analytical chemistry for the determination of enantiomeric purity and the study of chiral separation techniques, such as chromatography and capillary electrophoresis.
Check Digit Verification of cas no
The CAS Registry Mumber 876159-76-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,6,1,5 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 876159-76:
(8*8)+(7*7)+(6*6)+(5*1)+(4*5)+(3*9)+(2*7)+(1*6)=221
221 % 10 = 1
So 876159-76-1 is a valid CAS Registry Number.
876159-76-1Relevant academic research and scientific papers
Enriching the arsenal of pharmacological tools against mical2
Angeloni, Debora,Barravecchia, Ivana,Barresi, Elisabetta,Brancaccio, Diego,Da Settimo, Federico,De Cesari, Chiara,De Luca, Davide,Donati, Greta,Giustiniano, Mariateresa,La Pietra, Valeria,Marinelli, Luciana,Mignucci, Valerio,Pelliccia, Sveva,Russo, Camilla,Salerno, Silvia,Scebba, Francesca,Taliani, Sabrina
, (2021/12/24)
Molecule interacting with CasL 2 (MICAL2), a cytoskeleton dynamics regulator, are strongly expressed in several human cancer types, especially at the invasive front, in metastasizing cancer cells and in the neo-angiogenic vasculature. Although a plethora of data exist and stress a growing relevance of MICAL2 to human cancer, it is worth noting that only one small-molecule inhibitor, named CCG-1423 (1), is known to date. Herein, with the aim to develop novel MICAL2 inhibitors, starting from CCG-1423 (1), a small library of new compounds was synthetized and biologically evaluated on human dermal microvascular endothelial cells (HMEC-1) and on renal cell adenocarcinoma (786-O) cells. Among the novel compounds, 10 and 7 gave interesting results in terms of reduction in cell proliferation and/or motility, whereas no effects were observed in MICAL2-knocked down cells. Aside from the interesting biological activities, this work provides the first structure–activity relationships (SARs) of CCG-1423 (1), thus providing precious information for the discovery of new MICAL2 inhibitors.
