876189-27-4Relevant academic research and scientific papers
A short synthesis of lennoxamine via ynamides
Couty, Sylvain,Meyer, Christophe,Cossy, Janine
, p. 767 - 769 (2007/10/03)
Lennoxamine was synthesized in eight steps from 2,3-dimethoxybenzoic acid via an intermediate ynamide by using palladium-catalyzed Heck-Suzuki-Miyaura domino reactions.
Synthesis of 3-(arylmethylene)isoindolin-1-ones from ynamides by Heck-Suzuki-Miyaura domino reactions. Application to the synthesis of lennoxamine
Couty, Sylvain,Liegault, Beno?t,Meyer, Christophe,Cossy, Janine
, p. 3882 - 3895 (2007/10/03)
Substituted 3-(arylmethylene)isoindolin-1-ones can be efficiently synthesized from various ynamides and boronic acids by palladium-catalyzed Heck-Suzuki-Miyaura domino reactions. This methodology has been applied to the total synthesis of lennoxamine and a concise route to this isoindolobenzazepine alkaloid was achieved in eight steps from 2,3-dimethoxybenzoic acid via a key intermediate ynamide.
