876191-41-2

Basic information

• Product Name: tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate
• CAS NO: 876191-41-2
• Molecular Weight: 621.776
• Mol File: 876191-41-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate(876191-41-2)
• EPA Substance Registry System: tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate(876191-41-2)

Safety Data

• Hazardous Substances Data: 876191-41-2(Hazardous Substances Data)

Upstream product

• 41808-35-9 5-amino-4-cyano-3-methylisothiazole 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 116595-42-7 (2E)-2-cyano-3-ethoxybut-2-enethioamide 
• 758721-53-8 (2E)-3-amino-2-cyanobut-2-enethioamide 
• 758722-09-7 tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]amino]propyl]carbamate 
• 59189-97-8 3-fluoro-4-methylbenzoic acid chloride 
• 758722-07-5 6-(1-amino-2-methylpropyl)-5-benzyl-3-methyl-[1,2]thiazolo[4,5-e]pyrimidin-4-one 
• 758722-05-3 6-(1-azido-2-methylpropyl)-5-benzyl-3-methyl-[1,2]thiazolo[4,5-e]pyrimidin-4-one 
• 758722-00-8 3-methyl-6-(2-methylpropyl)-5H-[1,2]thiazolo[4,5-e]pyrimidin-4-one 
• 162702-36-5 3-methyl-5-(3-methylbutanoylamino)-1,2-thiazole-4-carboxamide 
• 162702-04-7 N-(4-cyano-3-methyl-1,2-thiazol-5-yl)-3-methylbutanamide 

Relevant articles and documents

Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2] thiazolo[5,4- d ]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent

Structure-activity relationship analysis identified (+)-N-(3-aminopropyl)- N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl) -2-methylpropyl]-4-methylbenzamide (AZD4877), from a series of novel kinesin spindle protein (KSP) inhibitors, as exhibiting both excellent biochemical potency and pharmaceutical properties suitable for clinical development. The selected compound arrested cells in mitosis leading to the formation of the monopolar spindle phenotype characteristic of KSP inhibition and induction of cellular death. A favorable pharmacokinetic profile and notable in vivo efficacy supported the selection of this compound as a clinical candidate for the treatment of cancer.