87626-26-4Relevant academic research and scientific papers
Benzomorphan related compounds. XVII. Oxidative cyclization of N-arylethyl-6,7-benzomorphan
Bosch,Domingo,Granados
, p. 887 - 891 (1983)
The synthesis of two new bridged polycyclic systems (I and II), possessing a rigid N-arylethylbenzomorphan structure, by mercuric acetate cyclization of the corresponding seco derivatives (IV and VI, respectively) is described. The relative configuration of these compounds and the preferred indolo[2,3-a]- or benzo[a]quinolizidine conformation is assigned.
Benzomorphans useful as NMDA receptor antagonists
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, (2008/06/13)
Compounds of the formula I STR1 are disclosed. In this formula, R is a member selected from the group consisting of --CR 1 R 2 R 3, hydroxy, an alkoxy group having 1 to 4 carbon atoms and --NR 4 R 5, in which at most one of R 1, R 2 and R 3 is hydrogen and the remainder are each independently selected from the group consisting of an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, an alkynyl group having 2 to 4 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, a cycloalkylalkyl having 4 to 9 carbon atoms and a 3 to 6 membered cyclic ether; R 4 and R 5 are each independently hydrogen or an alkyl group having 1 to 4 carbon atoms; R 6 and R 7 are each independently hydrogen or an alkyl group having 1 to 4 carbon atoms; and R 8 is hydrogen, an alkyl group having 1 to 4 carbon atoms, hydroxy, an alkoxy group having 1 to 4 carbon atoms or halogen. Salts of these compounds are also disclosed. Also disclosed are pharmaceutical compositions of these compounds with a pharmaceutically acceptable carrier, the use of these materials as N-methyl-D-aspartate receptor antagonists, processes for preparing these compounds and salts, and methods to treat cerebral diseases by administering an effective amount of these compounds, salts or compositions.
