876269-60-2Relevant academic research and scientific papers
Enantioselective nitroaldol reaction of α-keto esters catalyzed by a copper(II)-bisoxazolidine complex
Xu, Hanhui,Wolf, Christian
experimental part, p. 2765 - 2770 (2011/02/22)
A wide range of aliphatic and aromatic -keto esters has been transformed to α-hydroxy-β-nitro esters via the Cu(II)-bisoxa-zolidine-catalyzed Henry reaction. In the presence of 10 mol% of the chiral catalyst, nitroaldol products were obtained in up to 95% yield and 76% ee.
Enantioselective addition of nitromethane to α-keto esters catalyzed by copper(II)-iminopyridine complexes
Blay, Gonzalo,Hernandez-Olmos, Victor,Pedro, Jose R.
experimental part, p. 468 - 476 (2008/10/09)
The copper complex of a chiral iminopyridine easily prepared from (R)-(-)-fenchone and picolylamine catalyzes the enantioselective Henry (nitroaldol) reaction between nitromethane and α-keto esters. Good yields and modest to good enantioselectivities are obtained for a wide range of α-keto esters, bearing aromatic, alkyl or alkenyl groups attached to the ketone carbonyl group. The Royal Society of Chemistry 2008.
