302912-31-8

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 4-CYANOBENZOYLFORMATE is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the efficacy of existing ones. Its role in the production of complex organic molecules makes it an essential component in the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL 4-CYANOBENZOYLFORMATE is utilized as a precursor in the synthesis of agrochemicals, aiding in the development of more effective and environmentally friendly pesticides and other agricultural products.
Used in Organic Chemistry Research:
ETHYL 4-CYANOBENZOYLFORMATE is employed as a reagent in various organic chemistry reactions, particularly in the synthesis of heterocyclic compounds. Its versatility in forming different chemical structures makes it a valuable tool for researchers in the field of organic chemistry.
Used in Chemical Synthesis:
As a building block in chemical synthesis, ETHYL 4-CYANOBENZOYLFORMATE is used to construct complex organic molecules, facilitating the creation of new compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C11H9NO3/c1-2-15-11(14)10(13)9-5-3-8(7-12)4-6-9/h3-6H,2H2,1H3

Upstream product

• 64-17-5 ethanol 
• 3032-92-6 4-cyanophenylacetylene 
• 1443-80-7 4-cyanophenyl methyl ketone 
• 140-89-6 potassium ethyl xanthogenate 
• 623-00-7 4-bromobenzenecarbonitrile 
• 95-92-1 oxalic acid diethyl ester 
• 25309-65-3 4-ethylbenzonitrile 
• 141-78-6 ethyl acetate 

Downstream Products

• 450844-51-6 (4-cyanophenyl)-2-oxo-acetic acid (1R,2S,5R)-menthyl ester 
• 6051-67-8 1,4-benzenemonoketodicarboxylic acid 
• 876269-60-2 (R)-(-)-ethyl 2-(4-cyanophenyl)-2-hydroxy-3-nitropropanoate 
• 847227-46-7 ethyl 2-(4-cyanophenyl)-2-hydroxyacetate 

Relevant academic research and scientific papers

Tris(pentafluorophenyl)borane-Catalyzed Oxygen Insertion Reaction of α-Diazoesters (α-Diazoamides) with Dimethyl Sulfoxide

A tris(pentafluorophenyl)borane-catalyzed oxidation reaction of α-diazoesters (α-diazo amides) with dimethyl sulfoxide has been developed. The reaction proceeds under metal free conditions to afford a series α-ketoesters and α-ketoamides. The synthetic utility of this protocol is demonstrated through synthetic transformations and scaled-up synthesis. (Figure presented.).

Metal-Free Oxidative Esterification of Ketones and Potassium Xanthates: Selective Synthesis of α-Ketoesters and Esters

A novel and efficient oxidative esterification for the selective synthesis of α-ketoesters and esters has been developed under metal-free conditions. In the protocol, various α-ketoesters and esters are available in high yields from commercially available ketones and potassium xanthates. Mechanistic studies have proven that potassium xanthate not only promotes oxidative esterification but also provides an alkoxy moiety for the reaction, which involves the cleavage and reconstruction of C-O bonds.

Ambient and aerobic carbon-carbon bond cleavage toward α-ketoester synthesis by transition-metal-free photocatalysis

The α-oxoesterification of the CC double bond in readily available enaminones enabling efficient synthesis of α-ketoesters is developed. The reactions showing general tolerance to the reactions of primary and secondary alcohols proceed well under air via Rose Bengal (RB)-based photocatalysis. Particularly, this mild synthetic method has been discovered to tolerate various polyhydroxylated substrates such as phenolic alcohol, diols and triols with an excellent selectivity of mono-oxoesterification. What is more noteworthy is that α-ketoester functionalized 16-dehydropregnenolone acetate resulting from the elaboration on a natural product has been obtained practically.

In Situ Generated AgII-Catalyzed Selective Oxo-Esterification of Alkyne with Alcohol to α-Ketoester: Photophysical Study

An expert and easy one-step catalytic method for the multi O-C coupling of alkyne is developed for the synthesis of valuable α-ketoesters and their chiral analogues, in contrast to the generation of esters by a noncatalytic method. The in situ generated powerful AgII catalyst from AgOTf is the workhorse in the oxidative grafting of alkyne with PhIO and alcohol. The radical mechanism is confirmed in our controlled experiments and UV-vis study.

Reactions of organolithiums with dialkyl oxalates. A flow microreactor approach to synthesis of functionalized α-keto esters

Reactions of functionalized aryllithiums with dialkyl oxalates were achieved using a flow microreactor to obtain α-keto esters with high selectivity by virtue of fast 1:1 micromixing.

Direct synthesis of α-keto esters from ethylbenzenes using 48% aqueous HBr by aerobic visible light photooxidation

We report that ethylbenzenes can be directly oxidized to the corresponding -keto esters with molecular oxygen in the presence of 48% aqueous HBr under visible light irradiation. This synthetic procedure is the first example for direct preparation of the corresponding α-keto esters from ethylbenzenes. Georg Thieme Verlag Stuttgart - New York.