876316-36-8

Basic information

• Product Name: 1-Methyl-1H-indole-4-sulfonyl chloride
• Synonyms: 1-METHYL-1H-INDOLE-4-SULFONYL CHLORIDE;1-METHYL-1H-INDOLE-4-SULPHONYL CHLORIDE;1-Methyl-1H-indole-4-sulphonyl chloride 97%;4-(Chlorosulphonyl)-1-methyl-1H-indole;1-Methyl-1H-indole-4-sulphonylchloride97%
• CAS NO: 876316-36-8
• Molecular Formula: C₉H₈ClNO₂S
• Molecular Weight: 229.68332
• Mol File: 876316-36-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 94 °C
• Boiling Point: 382.9 °C at 760 mmHg
• Flash Point: 185.4 °C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 1.01E-05mmHg at 25°C
• Refractive Index: 1.631
• CAS DataBase Reference: 1-Methyl-1H-indole-4-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-indole-4-sulfonyl chloride(876316-36-8)
• EPA Substance Registry System: 1-Methyl-1H-indole-4-sulfonyl chloride(876316-36-8)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 876316-36-8(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-indole-4-sulfonyl chloride is a chemical compound with the molecular formula C9H8ClNO2S. It is a sulfonyl chloride derivative of 1-methyl-1H-indole-4-sulfonic acid and is commonly used as a reagent in organic synthesis. 1-Methyl-1H-indole-4-sulfonyl chloride is often utilized in the preparation of various indole derivatives, which are important building blocks in the pharmaceutical and agrochemical industries. 1-Methyl-1H-indole-4-sulfonyl chloride is known for its ability to undergo nucleophilic substitution reactions, making it a valuable tool in the production of a wide range of organic compounds with diverse applications.

InChI:InChI=1/C9H8ClNO2S/c1-11-6-5-7-8(11)3-2-4-9(7)14(10,12)13/h2-6H,1H3

Upstream product

• 590417-55-3 4-bromo-1-methyl-1H-indole 

Relevant articles and documents

N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity

Compound 1 ((4-amino-3,5-dichlorophenyl)-1-(4-methylpiperidin-1-yl)-4-(2-nitroimidazol-1-yl)-1-oxobutane-2-sulfonamido) was discovered to be a 690 nM antagonist of human CCR10 Ca2+flux. Optimization delivered (2R)-4-(2-cyanopyrrol-1-yl)-S-(1H-indol-4-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutane-2-sulfonamido (eut-22) that is 300 fold more potent a CCR10 antagonist than 1 and eliminates potential toxicity, mutagenicity, and drug–drug-interaction liabilities often associated with nitroaryls and anilines. eut-22 is highly selective over other GPCR's, including a number of other chemokine receptors. Finally, eut-22 is efficacious in the murine DNFB model of contact hypersensitivity. The efficacy of this compound provides further evidence for the role of CCR10 in dermatological inflammatory conditions.