35944-64-0

Basic information

• Product Name: 3-IODO-4-METHYLANILINE
• Synonyms: 3-iodo-p-toluidine;3-IODO-PARA-TOLUIDINE;(3-iodo-4-methyl-phenyl)amine;3-iodo-4-methylbenzenamine;3-Iodo-4-methylaniline 97%;4-AMINO-2-IODOTOLUENE;3-IODO-4-METHYLANILINE;3-iodo-p-toluidin
• CAS NO: 35944-64-0
• Molecular Formula: C₇H₈IN
• Molecular Weight: 233.05
• EINECS: 252-803-2
• Product Categories: Anilines, Amides & Amines;Iodine Compounds;Amines;C7;Nitrogen Compounds
• Mol File: 35944-64-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 37-41 °C(lit.)
• Boiling Point: 289.4 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: light brown solid
• Density: 1.791 g/cm³
• Vapor Pressure: 0.00759mmHg at 25°C
• Refractive Index: 1.663
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.07±0.10(Predicted)
• Water Solubility: Insoluble in water.
• Sensitive: Light Sensitive
• BRN: 2353567
• CAS DataBase Reference: 3-IODO-4-METHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-4-METHYLANILINE(35944-64-0)
• EPA Substance Registry System: 3-IODO-4-METHYLANILINE(35944-64-0)

Safety Data

• Hazard Codes: T
• Statements: 25-41-43
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: XU7700000
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 35944-64-0(Hazardous Substances Data)

Usage

Uses

3-Iodo-4-methylaniline is used as fine chemicals, pharmaceutical intermediates. 2-[((3-iodo-4-methyl)phenylimino)methyl]-5-nitrothiophene was derived from 5-nitro-2-thiophene-carboxaldehyde and 3-iodo-4-methylaniline. 1-(3-iodo-4-methylphenyl)-3-tert-butyl-2H-aminopyrazole (5), prepared from 3-iodo-4-methylaniline.

InChI:InChI=1/C7H8IN/c1-5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3

Upstream product

• 122099-11-0 4-azido-2-iodotoluene 
• 109-89-7 diethylamine 
• 106-49-0 p-toluidine 
• 99-94-5 p-Toluic acid 
• 82998-57-0 3-iodo-4-toluic acid 
• 7647-01-0 hydrogenchloride 
• 858846-58-9 2,6-dibromo-3-iodo-4-methyl-aniline 
• 64-19-7 acetic acid 
• 876494-97-2 2-bromo-5-iodo-4-methyl-aniline 
• 858846-53-4 2,5-diiodo-4-methyl-aniline 
• 7745-92-8 2-iodo-1-methyl-4-nitrobenzene 

Downstream Products

• 872822-81-6 (3-iodo-4-methyl-phenyl)-urea 
• 858846-53-4 2,5-diiodo-4-methyl-aniline 
• 858846-58-9 2,6-dibromo-3-iodo-4-methyl-aniline 
• 585544-17-8 2-chloro-N-(3-iodo-4-methylphenyl)-isonicotinamide 
• 1233937-12-6 cyclohexyl 3,3-bis(2-methyl-5-aminophenyl)acrylate 
• 911693-52-2 3-fluoro-N-(3-iodo-4-methylphenyl)-4-methylbenzamide 
• 1600517-79-0 C₁₀H₁₂IN 
• 1600517-80-3 N,N-diallyl-3-iodo-4-methylaniline 
• 311331-96-1 2-[((3-iodo-4-methyl)phenylimino)methyl]-5-nitrothiophene 

Relevant articles and documents

Complementary Site-Selective Halogenation of Nitrogen-Containing (Hetero)Aromatics with Superacids

Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5, the chlorination and iodination of classically inert Csp2?H bonds of aromatic amines occurs. Furthermore, the superacid-promoted (poly)protonation of the molecules acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients.