876360-92-8Relevant academic research and scientific papers
Guanidine and 2-aminoimidazoline aromatic derivatives as α2-adrenoceptor ligands: Searching for structure-activity relationships
Rodriguez, Fernando,Rozas, Isabel,Ortega, Jorge E.,Erdozain, Amaia M.,Meana, J. Javier,Callado, Luis F.
supporting information; experimental part, p. 601 - 609 (2009/11/30)
In this paper, we report the synthesis of three new 2-aminoimidazoline (compounds 4b, 5b, and 6b) and three new guanidine derivatives (compounds 7b, 8b, and 9b) as potential α2-adrenoceptor antagonists for the treatment of depression. Their pha
Development of N-4,6-pyrimidine-N-alkyl-N′-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase
Maier, Jennifer A.,Brugel, Todd A.,Sabat, Mark,Golebiowski, Adam,Laufersweiler, Matthew J.,VanRens, John C.,Hopkins, Corey R.,De, Biswanath,Hsieh, Lily C.,Brown, Kimberly K.,Easwaran, Vijayasurian,Janusz, Michael J.
, p. 3646 - 3650 (2007/10/03)
A new class of lymphocyte specific tyrosine kinase (lck) inhibitors based on an N-4,6-pyrimidine-N-alkyl-N′-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar inhibition of lck kinase activity as well as IL-2 synthesis from Ju
