876391-75-2Relevant academic research and scientific papers
Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720
Lu, Xuequan,Sun, Chaode,Valentine, William J.,Shuyu,Liu, Jianxiong,Tigyi, Gabor,Bittman, Robert
experimental part, p. 3192 - 3195 (2009/09/30)
The first enantioselective synthesis of chiral isosteric phosphonate analogues of FTY720 is described. One of these analogues, FTY720-(E)- vinylphosphonate (S)-5, but not its R enantiomer, elicited a potent antiapoptotic effect in intestinal epithelial ce
Enantioselective synthesis of the phosphate esters of the immunosuppressive lipid FTY720
Lu, Xuequan,Bittman, Robert
, p. 825 - 827 (2007/10/03)
The enantiomers of FTY720-phosphate (3) were synthesized via 2-methylene-4-(4-octylphenyl)butan-1-ol (7), 2,3-epoxy alcohol 8, and Δ2-oxazoline 10. These compounds have potential use in the treatment of autoimmune diseases and prevention of kid
