876460-09-2

Upstream product

• 882866-44-6 3-iodo-2-(4'-methoxyphenyl)-quinolin-4(1H)-one 
• 74-88-4 methyl iodide 
• 579-72-6 2-(dimethylamino)benzaldehyde 
• 246181-55-5 1-methyl-2-(4’-methoxyphenyl)-1H-4-quinolone 
• 33768-41-1 N-(2-acetyl-phenyl)-4-methoxy-benzamide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 876460-07-0 1-(2-dimethylaminophenyl)-3-(4-methoxyphenyl)prop-2-yn-1-one 
• 876460-05-8 1-(2-dimethylaminophenyl)-3-(4-methoxyphenyl)prop-2-yn-1-ol 
• 3813-92-1 2-(4-methoxyphenyl)-1,4-dihydro-4-oxoquinoline 

Downstream Products

• 1309362-45-5 4-methoxy-N-(2-(4-methoxyphenyl)-1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)benzamide 
• 246181-55-5 1-methyl-2-(4’-methoxyphenyl)-1H-4-quinolone 
• 1309362-54-6 N-(2-(4-methoxyphenyl)-1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)acetamide 

Relevant academic research and scientific papers

Synthesis and cyclisation studies of (E)-2-aryl-1-methyl-3-styrylquinolin-4(1H)-ones

The synthesis of (E)-2-aryl-1-methyl-3-styrylquinolin-4(1H)-ones, through the Heck reaction of 2-aryl-3-iodo-1-methyl-quinolin-4(1H)-ones with styrene is described. 2-Aryl-3-iodo-1-methyl-2-quinolin-4(1H)-ones can be obtained efficiently in a two-step tra

A general copper powder-catalyzed ullmann-type reaction of 3-halo-4(1 H)-quinolones with various nitrogen-containing nucleophiles

3-(N-Substituted) 4(1H)-quinolinones were synthesized using the copper-catalyzed Ullmann C-N bond forming strategy in moderate to quantitative yields. Starting from 3-halo-4(1H)-quinolones, various nucleophiles including amides, lactams, sulfonamides and NH-containing azoles have been used successfully. In all cases, the reactions take place rapidly in toluene and proceed by using copper powder as a catalyst, DMEDA as a ligand and K 2CO3 as a base. In addition, other related heterocycles such as 3-bromoquinolin-2(1H)-ones, 3-bromocoumarin, and 3,5-dibromo-2-pyridone show good to very high reactivity with various nucleophiles under our Cu/DMEDA catalyst system.

Selective endo and exo iodocyclizations in the synthesis of quinolines and indoles

A simple, efficient method for a divergent synthesis of indoles, quinolines, and quinolinones using a highly selective endo/exo iodocyclization procedure is described.

Synthesis and further studies of chemical transformation of the 2-aryl-3-halogenoquinolin-4(1H)-one derivatives

The C-3 brominated and iodinated derivatives were prepared from the corresponding 2-arylquinolin-4(1H)-ones and their NMe-4-oxo derivatives using pyridinium tribromide in acetic acid or iodine-Na2CO3 mixture in THF. The results of fu