87657-66-7

Upstream product

• 621-59-0 isovanillin 
• 14171-89-2 1-phenyl-5-hexanone 
• 4173-44-8 6-phenylhexa-3,5-dien-2-one 
• 123-75-1 pyrrolidine 
• 14371-10-9 (E)-3-phenylpropenal 

Downstream Products

• 78925-42-5 1-(3-hydroxy-4-methoxyphenyl)-7-phenyl-3-heptanone 

Relevant academic research and scientific papers

DIARYLALKANOIDS HAVING ACTIVITY AS LIPOXYGENASE INHIBITORS

The present invention is novel diarylalkanoids having activity as lipoxygenase inhibitors, novel pharmaceutical compositions therefor, and novel methods of use in treating asthma, allergies, cardiovascular diseases, migraines, psoriasis and immunoinflammatory diseases for diarylalkanoids. The compounds of this invention are also useful as cytoprotective agents.

Diarylalkanoids having activity as lipoxygenase inhibitors

The present invention is novel diarylalkanoids having activity as lipoxygenase inhibitors, novel pharmaceutical compositions therefor, and novel methods of use in treating asthma, allergies, cardiovascular diseases, migraines, psoriasis and immunoinflammatory diseases for diarylalkanoids. The compounds of this invention are also useful as cytoprotective agents.

Synthesis of diarylheptanoids and assessment of their pungency

With the aim of correlating pungency with substituent groups on one benzene ring, various analogues of yakuchinones were synthesized by means of the Claisen-Schmidt reaction. Their pungencies were assessed by direct comparison of the threshold concentrations obtained in taste experiments. The presence of a phenolic hydroxyl group was indispensable for high pungency, while that of a 1,2-double bond of the heptanone part tended to decrease the pungency.