87657-67-8

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 104-55-2 3-phenyl-propenal 
• 4173-44-8 1-phenyl-1,3-hexadien-5-one 
• 4173-44-8 6-phenylhexa-3,5-dien-2-one 
• 14171-89-2 1-phenyl-5-hexanone 
• 139-85-5 3,4-dihydroxybenzaldehyde 

Downstream Products

• 1443545-69-4 acetic acid (E)-2-acetoxy-4-(3-oxo-7-phenyl-hept-1-enyl)phenyl ester 
• 87657-72-5 1-(3,4-dihydroxyphenyl)-7-phenyl-3-heptanone 

Relevant academic research and scientific papers

Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation

E-3,4-Dihydroxy styryl aralkyl ketones as well as their 3,4-diacetylated derivatives as the analogues of neuroprotective agent CAPE were designed and synthesized for improving stability and lipid solubility. The neuroprotective activities of target compounds 10a-g and 11a-g were tested by three models in vitro, including 1,1-diphenyl-2-picrylhydrazyl radical scavenging capacity, neuronal protecting effect against damage induced by H2O2 in PC12 cells and nitric oxide suppression effect in BV2 microglial cells. The results demonstrated that compounds 10f and 11f exhibited the most potent neuroprotective effect against oxidative stress and inflammation, which is higher than that of the lead compound CAPE.

Synthesis of diarylheptanoids and assessment of their pungency

With the aim of correlating pungency with substituent groups on one benzene ring, various analogues of yakuchinones were synthesized by means of the Claisen-Schmidt reaction. Their pungencies were assessed by direct comparison of the threshold concentrations obtained in taste experiments. The presence of a phenolic hydroxyl group was indispensable for high pungency, while that of a 1,2-double bond of the heptanone part tended to decrease the pungency.