876710-04-2

Usage

Properties

1. Amino group
2. Hydroxymethyl group
3. Carbonitrile group
4. Pyrano pyran ring system
5. 3-methylphenyl group
6. Oxo group
7. Heterocyclic compound
8. Highly functionalized structure

Chemical compound

2-amino-6-(hydroxymethyl)-4-(3-methylphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

Structure

Complex

Potential uses

Medicinal chemistry, building block for synthesis of other complex molecules

Further investigation needed

Research and experimentation to determine specific properties and applications

Upstream product

• 501-30-4 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 
• 620-23-5 m-tolyl aldehyde 
• 109-77-3 malononitrile 
• 15728-26-4 2-(3-methylbenzylidene)malononitrile 

Relevant academic research and scientific papers

Microwave-assisted, water-mediated Michael addition for synthesis of kojic acid derivatives

A highly efficient method is described for the synthesis of substituted kojic acid derivatives in the presence of water under microwave irradiation. This transformation represents an efficient way to synthesize kojic acid derivatives from simple starting

Acetic Acid-Mediated Synthesis of Kojic Acid Derivatives

Abstract: A green acetic acid-mediated synthesis of kojic acid derivatives through amulticomponent reaction (MCR) has been developed. This new protocol is simpleand efficient; it involves a one-pot reaction of equimolar amounts of kojicacid, aromatic alde

One-pot synthesis of 2-amino-4,8-dihydropyrano[3,2-b]pyranes and pyridopyrimidines under mild conditions

1,8-Diazabicyclo[5.4.0]undec-7-ene immobilized on silica (SB-DBU)Cl as a reusable and heterogeneous catalyst was applied for the one-pot, three-component synthesis of 2-amino-4,8-dihydropyrano[3,2-b]pyrane-3-carbonitriles and pyridopyrimidines, under solvent-free conditions. The reaction was carried out at room temperature, and pure products were obtained in high yields and short reaction times (3–7 min). This work introduced an environmentally benign procedure for the synthesis of these classes of biological active compounds.

Supramolecular catalysis by β-cyclodextrin for the synthesis of kojic acid derivatives in water

An efficient and green method has been developed for the synthesis of kojic acid derivatives by employing 20 mol% β-cyclodextrin in aqueous media. The high functional group tolerance and shorter reaction times make this method suitable for the synthesis o

Synthesis, characterization, and application of Cu2O and NiO nanoparticles supported on natural nanozeolite clinoptilolite as a heterogeneous catalyst for the synthesis of pyrano[3,2-b]pyrans and pyrano[3,2-c]pyridones

In this research, Cu2O and NiO nanoparticles supported on natural nanozeolite clinoptilolite (CP) was found to be a recoverable catalyst system for synthesis of pyrano-[3,2-c]pyridone and pyrano[3,2-b]pyran derivatives in aqueous media. The nan

SiO2-OSO3H nanoparticles: An efficient, versatile and new reagent for the one-pot synthesis of 2-amino-8-oxo-4,8-dihydropyrano[3,2-b] pyran-3-carbonitrile derivatives in water, a green protocol

In a one-pot three-component reaction, an aromatic or aliphatic aldehyde, malononitrile and 5-hydroxy-2-hydroxymethyl-4H-pyran-4-one were condensed for the synthesis of 2-amino-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile derivatives in the presence of nano-silica sulfuric acid (SiO 2-OSO3H nanoparticles) in improved yields. The catalyst is recoverable by simple filtration and can be used in the subsequent reactions.

Ultrasound promoted one-pot synthesis of 2-amino-4,8-dihydropyrano[3,2-b] pyran-3-carbonitrile scaffolds in aqueous media: A complementary 'green chemistry' tool to organic synthesis

A green and simple approach to assembling of 2-amino-4,8-dihydropyrano[3,2- b]pyran-3-carbonitrile scaffolds via three-component reaction of kojic acid, malononitrile, and aromatic aldehydes in aqueous media under ultrasound irradiation is described. The combinatorial synthesis was achieved for this methodology with applying ultrasound irradiation while making use of water as green solvent. In comparison to conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and selectivity without the need for a transition metal or base catalyst are prominent features of this green procedure.

Nanozeolite clinoptilolite as a highly efficient heterogeneous catalyst for the synthesis of various 2-amino-4H-chromene derivatives in aqueous media

The preparation of pharmaceutically active 2-amino-4H-chromene derivatives has been achieved using a nano powder of natural clinoptilolite (CP) zeolite. A wide range of these worthy structures having diverse substituents on the 4H-chromene ring were effic