876716-11-9

Usage

Uses

Used in Pharmaceutical Industry:
3-(3-Pyridin-3-yl-1,2,4-oxadiazol-5-yl)propanoic acid is used as a building block for the synthesis of potential pharmaceutical compounds due to its potential bioactivity and valuable scaffold for drug development.
Used in Medicinal Chemistry Research:
3-(3-Pyridin-3-yl-1,2,4-oxadiazol-5-yl)propanoic acid is used as a research compound for further studies and potential applications in the field of medicinal chemistry, given its unique structure and properties.

InChI:InChI=1/C10H9N3O3/c14-9(15)4-3-8-12-10(13-16-8)7-2-1-5-11-6-7/h1-2,5-6H,3-4H2,(H,14,15)

Upstream product

• 108-30-5 succinic acid anhydride 
• 1311581-91-5 C₁₁H₁₁N₃O₃ 
• 1594-58-7 nicotinamide oxime 
• 100-54-9 pyridine-3-carbonitrile 

Relevant academic research and scientific papers

Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety

An efficient and mild one-pot protocol has been developed for the synthesis of 1,2,4-oxadiazoles via the reaction of amidoximes with dicarboxylic acid anhydrides in a NaOH/DMSO medium. The method allows the synthesis of diversely substituted carboxylic acids bearing the 1,2,4-oxadiazole motif, – a popular building block for pharmaceutical research, in moderate to excellent yields. The reaction scope includes aromatic and heteroaromatic amidoximes as well as five-, six- and seven-membered anhydrides. The advantages of this procedure are proven gram-scalability and the use of inexpensive starting materials, which from a process chemistry point of view are essential for future industrial applications.

Synthesis, characterization, and antimicrobial activities of clubbed [1,2,4]-oxadiazoles with fluorobenzimidazoles

(Chemical Equation Presented) In this study, a novel series of substituted 4,6-difluoro-2-{2-[3-(substituted-phenyl)-[1,2,4]-oxadiazol-5-yl]-ethyl} -1H-benzo[d]imidazole derivatives were synthesized by condensation of 2,4-difluoro-6-nitrophenyl amine with 3-(substitutedphenyl-[1,2,4]-oxadiazol- 5yl) propionic acid by using 2,4,6-trichlorobenzoyl chloride in the presence of triethyl amine base. The compounds were evaluated for their preliminary in vitro antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Salmonella typhosa. The antibacterial data of the tested compounds indicated that most of the synthesized compounds showed moderate activity with reference standard Gentamycin.