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Usage

Physical appearance

Pale yellow liquid The compound has a light yellow color and is in a liquid state at room temperature.

Odor

Strong, sweet, floral The compound has a pleasant and intense aroma, reminiscent of flowers.

Use in perfumery

Commonly used in manufacturing perfumes and fragrances Due to its appealing scent, the compound is a popular choice for creating various fragrances.

Synthesis in pharmaceuticals

Used in the synthesis of pharmaceuticals The compound serves as a building block for creating various medications and other organic compounds.

Insecticidal properties

Can be used as an active ingredient in insect repellents and pest control products The compound has the ability to repel and control insects, making it a valuable component in related products.

Industrial applications

Range of uses 1-ETHYL-2,3-DIHYDRO-1H-INDOLE-5-CARBALDEHYDE is utilized in various industries, primarily for its aromatic and chemical properties.

Upstream product

• 5876-09-5 1-ethylindoline 
• 68-12-2 N,N-dimethyl-formamide 
• 496-15-1 1-indoline 

Relevant academic research and scientific papers

Novel non-carboxylate benzoylsulfonamide-based protein tyrosine phosphatase 1B inhibitors with non-competitive actions

A novel series of benzoylsulfonamide derivatives were synthesized and biologically evaluated. Among them, 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzamide (compound 18K) was identified as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with potent and selective inhibitory activity against PTP1B (IC50 = 0.25 μM). Compound 18K functioned as a non-competitive inhibitor and bound to the allosteric site of PTP1B. It also showed high oral absorption in mice (the maximum drug concentration (Cmax) = 45.5 μM at 30 mg/kg), rats (Cmax = 53.6 μM at 30 mg/kg), and beagles (Cmax = 37.8 μM at 10 mg/kg), and significantly reduced plasma glucose levels at 30 mg/kg/d (per os (p.o.)) for one week with no side effects in db/db mice. In conclusion, the substituted benzoylsulfonamide was shown to be a novel scaffold of a noncompetitive and allosteric PTP1B inhibitor, and compound 18K has potential as an efficacious and safe antidiabetic drug as well as a useful tool for investigations of the physiological and pathophysiological effects of allosteric PTP1B inhibition.

Novel non-carboxylate benzoylsulfonamide-based protein tyrosine phosphatase 1b inhibitors with non-competitive actions

A novel series of benzoylsulfonamide derivatives were synthesized and biologically evaluated. Among them, 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzamide (compound 18K) was identified as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with potent and selective inhibitory activity against PTP1B (IC50-0.25 μM). Compound 18K functioned as a non-competitive inhibitor and bound to the allosteric site of PTP1B. It also showed high oral absorption in mice (the maximum drug concentration (Cmax)-45.5 μM at 30 mg/kg), rats (Cmax-53.6 μM at 30 mg/kg), and beagles (Cmax-37.8 μM at 10 mg/kg), and significantly reduced plasma glucose levels at 30 mg/kg/d (per os (p.o.)) for one week with no side effects in db/db mice. In conclusion, the substituted benzoylsulfonamide was shown to be a novel scaffold of a noncompetitive and allosteric PTP1B inhibitor, and compound 18K has potential as an efficacious and safe antidiabetic drug as well as a useful tool for investigations of the physiological and pathophysiological effects of allosteric PTP1B inhibition.