5876-09-5

Basic information

• Product Name: 1H-Indole, 1-ethyl-2,3-dihydro-
• CAS NO: 5876-09-5
• Molecular Formula: C10H13N
• Molecular Weight: 147.22
• Mol File: 5876-09-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 1-ethyl-2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 1-ethyl-2,3-dihydro-(5876-09-5)
• EPA Substance Registry System: 1H-Indole, 1-ethyl-2,3-dihydro-(5876-09-5)

Safety Data

• Hazardous Substances Data: 5876-09-5(Hazardous Substances Data)

Usage

Indole derivative

A heterocyclic compound commonly found in nature and pharmaceuticals

Structural features

An ethyl group attached to the first carbon and a dihydrogroup attached to the second and third carbons

Physical properties

Colorless to pale yellow liquid with a slightly floral odor

Uses

Synthesis of pharmaceuticals and agrochemicals

Biological activities

Exhibits anti-inflammatory and anti-cancer properties, making it a compound of interest for potential therapeutic applications.

Upstream product

• 496-15-1 1-indoline 
• 74-85-1 ethene 
• 16078-30-1 1-Acetyl-2,3-dihydro-1H-indole 

Downstream Products

• 876716-77-7 1-ethyl-2,3-dihydro-1H-indole-5-carbaldehyde 
• 1598463-79-6 N-(2-(1-ethylindolin-5-yl)-2-phenylvinyl)-4-methylbenzenesulfonamide 
• 1598463-80-9 N-(2-(1-ethylindolin-5-yl)-2-phenylvinyl)-4-methylbenzenesulfonamide 
• 10604-59-8 N-Ethylindole 

Relevant articles and documents

Novel nonmetal catalytic bidirectional selective reduction method of tertiary aromatic amide

The invention relates to a novel effective bidirectional selective environment-friendly method for hydrosilation reduction of tertiary aromatic amide and an organic silicon reagent. The method comprises the following steps: selecting a nonmetal catalytic system, and selectively preparing a secondary or tertiary organic amine compound by successively catalyzing tertiary aromatic amide and cheap PHMS or triethoxysilane under a mild condition. By adopting the method, the bidirectional selective reduction of the tertiary aromatic amide is realized by innovatively utilizing an electronic effect and steric hindrance difference of an organic silicon reagent at first time, so that a brand new strategy is provided for the reduction of amide and derivative of the amide, the defects of the traditional method that the substrate functional group is poor in compatibility, the production cost is high and the like can be overcome, and the application prospect of the amine compound prepared in industrial production or laboratory is promising.

Ruthenium-catalyzed intermolecular coupling reactions of arylamines with ethylene and 1,3-dienes: Mechanistic insight on hydroamination vs ortho-C-H bond activation

(Chemical Equation Presented) The cationic ruthenium complex [(PCy 3)2(CO)(Cl)Ru=CHCH=C(CH3)2] +BF4- was found to be an effective catalyst for the coupling reaction of aniline and ethylene to form a ～1:1 ratio of N-ethylaniline and 2-methylquinoline products. The analogous reaction with 1,3-dienes resulted in the preferential formation of Markovnikov addition products. The normal isotope effect of kNH/kND = 2.2 (aniline and aniline-d7 at 80°C) and the Hammett ρ = -0.43 (correlation of para-substituted p-X-C6H4NH2) suggest an N-H bond activation rate-limiting step for the catalytic reaction.