876716-86-8Relevant academic research and scientific papers
N-methylation of the C3′ amide of taxanes: Synthesis of N-methyltaxol C and N-methylpaclitaxel
Santhapuram, Hari K. R.,Datta, Apurba,Hutt, Oliver E.,Georg, Gunda I.
, p. 4705 - 4708 (2008)
(Chemical Equation Presented) A method has been developed for the methylation of the C3′ amide of taxol C and paclitaxel. Taxol C and paclitaxel were sequentially silylated at the 2′, 7, and 1-hydroxyl groups with tert-butyldimethylsilyl chloride, triethy
Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells
Spletstoser, Jared T.,Turunen, Brandon J.,Desino, Kelly,Rice, Antonie,Datta, Apurba,Dutta, Dinah,Huff, Jacquelyn K.,Himes, Richard H.,Audus, Kenneth L.,Seelig, Anna,Georg, Gunda I.
, p. 495 - 498 (2007/10/03)
A single-site modification of paclitaxel analogs at the C10 position on the baccatin III core that reduces interaction with P-glycoprotein in bovine brain microvessel endothelial cells is described. Modification and derivatization of the C10 position were
